Results 11 to 20 of about 7,879 (137)

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis [PDF]

open access: yesNature Communications, 2023
Cancer-associated fibroblasts (CAFs) are the main component of the stroma in pancreatic cancer, but their tissue of origin remains to be defined. Here the authors perform lineage tracing and single cell RNA sequencing in mice and suggest the splanchnic ...
Lu Han   +18 more
doaj   +2 more sources

Five patients with disorders of calcium metabolism presented with GCM2 gene variants [PDF]

open access: yesScientific Reports, 2021
The GCM2 gene encodes a transcription factor predominantly expressed in parathyroid cells that is known to be critical for development, proliferation and maintenance of the parathyroid cells.
Alejandro García-Castaño   +18 more
doaj   +2 more sources

Novel variant in the CNNM2 gene associated with dominant hypomagnesemia. [PDF]

open access: yesPLoS ONE, 2020
The maintenance of magnesium (Mg2+) homeostasis is essential for human life. The Cystathionine-β-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) have been described to be involved in maintaining Mg2+ homeostasis.
Alejandro García-Castaño   +15 more
doaj   +3 more sources

Genetic profile of a large Spanish cohort with hypercalcemia [PDF]

open access: yesFrontiers in Endocrinology
IntroductionThe disorders in the metabolism of calcium can present with manifestations that strongly suggest their diagnosis; however, most of the time, the symptoms with which they are expressed are nonspecific or present only as a laboratory finding ...
Alejandro García-Castaño   +13 more
doaj   +2 more sources

Risk and impact of stroke across 38 countries and territories of the Americas from 1990 to 2021: a population-based trends analysis from the Global Burden of Disease Study 2021Research in context [PDF]

open access: yesThe Lancet Regional Health. Americas
Summary: Background: Despite substantial declines in burden over time, stroke remains a public health threat in the Americas. This study aimed to assess the current magnitude, trends, and disparities in the estimates of stroke burden by sex and age in ...
Ramón Martinez   +38 more
doaj   +2 more sources

Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 studyResearch in context [PDF]

open access: yesThe Lancet Regional Health. Western Pacific
Summary: Background: There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate
Xin Hu   +678 more
doaj   +2 more sources

Test for Respiratory and Asthma Control in Kids (TRACK): validation of the Portuguese version [PDF]

open access: yesWorld Allergy Organization Journal, 2018
Background TRACK (Test for Respiratory and Asthma Control in Kids) questionnaire is an instrument developed and validated in English to evaluate the control of respiratory symptoms in children under 5 years of age.
Gustavo F. Wandalsen   +11 more
doaj   +2 more sources

Identification of a novel large CASR deletion in a patient with familial hypocalciuric hypercalcemia [PDF]

open access: yesEndocrinology, Diabetes & Metabolism Case Reports, 2018
Familial hypocalciuric hypercalcemia type I is an autosomal dominant disorder caused by heterozygous loss-of-function mutations in the CASR gene and is characterized by moderately elevated serum calcium concentrations, low urinary calcium excretion and ...
Alejandro García-Castaño   +9 more
doaj   +2 more sources

Immunogenicity of a third dose with mRNA-vaccines in the ChAdOx1-S/BNT162b2 vaccination regimen against SARS-CoV-2 variants [PDF]

open access: yesiScience
Summary: CombiVacS study has demonstrated a strong immune response of the heterologous ChAdOx1-S/BNT162b2 vaccine combination. The primary outcomes of the study were to assess the humoral immune response against SARS-CoV-2, 28 days after a third dose of ...
Javier García-Pérez   +125 more
doaj   +2 more sources

A circular RNA vector for targeted plant gene silencing based on an asymptomatic viroid. [PDF]

open access: yesPlant J, 2022
Significance Statement We developed a standardized viroid‐based procedure (termed VdIGS) for targeted silencing of eggplant genes. Modified ELVd variants (with insertions up to 42 nt) are able to replicate and induce systemic infection in host plants. This innovative approach constitutes the first use of biological forms of viroids as a tool for plant ...
Marquez-Molins J   +4 more
europepmc   +2 more sources

Home - About - Disclaimer - Privacy