Results 131 to 140 of about 2,005,973 (405)
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Host-Gut Microbiota Metabolic Interactions
Science, 2012 The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style.
J. Nicholson +6 more
semanticscholar +1 more source
Updated values of running quark and lepton masses at GUT scale in SM, 2HDM and MSSM [PDF]
Horizon, A Journal of Physics, Vol 2, 2013 (ISSN 2250-0871), 2012 Updated values of running quark and lepton masses at GUT (Grand unified theories) scales are important for fermion mass model building, and to calculate neutrino masses, in GUTs . We present their values at GUT scales, in SM, MSSM and 2HDM theories, using the latest values of running quark and lepton masses.
arxiv
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Gravitational GUT Breaking and the GUT-Planck Hierarchy
, 1995 It is shown that non-renormalizable gravitational interactions in the Higgs sector of supersymmetric grand unified theories (GUT's) can produce the breaking of the unifying gauge group $G$ at the GUT scale $M_{\rm GUT} \sim 10^{16}$~GeV.
A. Anselm +12 more
core +2 more sources
Gut Symptoms, Gut Dysbiosis and Gut-Derived Toxins in ALS
International Journal of Molecular SciencesMany pathogenetic mechanisms have been proposed for amyotrophic lateral sclerosis (ALS). Recently, there have been emerging suggestions of a possible role for the gut microbiota. Gut microbiota have a range of functions and could influence ALS by several mechanisms. Here, we review the possible role of gut-derived neurotoxins/excitotoxins.
Lee, Aven +3 more
openaire +2 more sources
SHOULD SPARTICLE MASSES UNIFY AT THE GUT SCALE? [PDF]
arXiv, 1995 Gauge and Yukawa (for the third family) coupling unification seem to be the best predictions of the grand-unified theories (GUTs). In supersymmetric GUTs, one also expects that the sparticle masses unify at the GUT scale (for sparticles embedded in the same GUT multiplet).
arxiv
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
Czy możliwa jest wolność bez wolnej woli? (IS FREEDOM WITHOUT FREE WILL POSSIBLE?) [PDF]
Analiza i Egzystencja, 2008 The main aim of this presents paper is to critically explore the view according to which an understanding and grasping of freedom is possible in the absence of free will.
Przemysław Gut
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