Results 131 to 140 of about 2,342,108 (381)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Overweight and obesity are associated with colorectal neoplasia in an Australian outpatient population

Scientific Reports
Colorectal cancer is a major cause of cancer-related deaths within the Australian population. Colonoscopy and polypectomy represent effective forms of prevention.
Rina Kumar, Allison Brown, Satomi Okano, Lisa Simms, Anton Lord, Timothy O’Sullivan, Gunter Hartel, Graham L. Radford-Smith   +7 more
doaj   +1 more source

Novel insights into carbohydrate utilisation, antimicrobial resistance, and sporulation potential in Roseburia intestinalis isolates across diverse geographical locations

Gut Microbes
Roseburia intestinalis is one of the most abundant and important butyrate-producing human gut anaerobic bacteria that plays an important role in maintaining health and is a potential next-generation probiotic. We investigated the pangenome of 16 distinct
Indrani Mukhopadhya, Jennifer C. Martin, Sophie Shaw, Martin Gutierrez-Torrejon, Nikoleta Boteva, Aileen J. McKinley, Silvia W. Gratz, Karen P. Scott   +7 more
doaj   +1 more source

Gut hormones [PDF]

Current Opinion in Gastroenterology, 1978
S R, Bloom, J M, Polak
openaire   +3 more sources

Additional file 3 of Assessment of bidirectional relationships between 98 genera of the human gut microbiota and amyotrophic lateral sclerosis: a 2-sample Mendelian randomization study

, 2022
Linjing Zhang, Zhenhuang Zhuang, Gan Zhang, Tao Huang, Dongsheng Fan   +4 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Anja Tews, Die Kriminalverfassung in Neuvorpommern undRügen 1815-1851. Ein Beitrag zur preußischen Justizgeschichte, 2004

Czasopismo Prawno-Historyczne, 2007
Recenzja: Anja Tews, Die Kriminalverfassung in Neuvorpommern und Rügen 1815-1851.
Paweł Gut
doaj   +1 more source

Labour Market Responses of survival pensioners: estimating a labour supply model and predicting the effect of the reform [PDF]

In this paper we use a sample of administrative data coming from the `Dataware-house labour market and social protection' and the microsimulation model MIMOSIS to assess the labour supply effects of a reform of the rules for cumulating labour income with
André Decoster, Gut Van Camp, Kristian Orsini   +2 more
core  

β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells. [PDF]

, 2020
Background & aimsIntegrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) and ...
Eckmann, Lars, Ginsberg, Mark H, Kuk, Wun, Lopez-Ramirez, Miguel Alejandro, Rivera-Nieves, Jesús, Sun, Hao   +5 more
core   +1 more source