Results 81 to 90 of about 114,048 (309)

Gut microbes with the gbu genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition [PDF]

[[abstract]]Gut microbial metabolism of L-carnitine, which leads to the production of detrimental trimethylamine N-oxide (TMAO), offers a plausible link between red meat consumption and cardiovascular risks. Several microbial genes, including cntA/B, the
Wu, WK;Lo, YL;Chiu, JY;Hsu, CL;Lo, IH;Panyod, S;Liao, YC;Chiu, THT;Yang, YT;Kuo, HC;Zou, HB;Chen, YH;Chuang, HL;Yen, JJY;Wang, JT;Chiu, HM;Hsu, CC;Kuo, CH;Sheen, LY;Kao, HL;Wu, MS
core   +1 more source

Effects of fecal microbiota transplantation in subjects with irritable bowel syndrome are mirrored by changes in gut microbiome [PDF]

, 2020
Irritable bowel syndrome (IBS) is a common disorder of the lower gastrointestinal tract. The pathophysiology is far from settled, but a gut microbial dysbiosis is hypothesized to be a contributing factor.
Johnsen, Peter Holger, Valle, Per Christian, Hilpüsch, Frank, Hjerde, Erik, Goll, Rasmus, Diab, Joseph, Cavanagh, Jorunn Pauline   +6 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut–Brain Axis [PDF]

, 2022
Over the last few years, the microbiome has emerged as a high-priority research area to discover missing links between brain health and gut dysbiosis. Emerging evidence suggests that the commensal gut microbiome is an important regulator of the gut–brain
Sarma, Devojit Kumar, Poonam Sharma, Manoj Kumar, Shubham, Swasti, Swasti Shubham, Kumawat, Manoj, Singh, Samradhi, Samradhi Singh, Kumar, Manoj, Devojit Kumar Sarma, Nagpal, Ravinder, Namrata Pal, Sharma, Poonam, Ravinder Nagpal, Pal, Namrata, Manoj Kumawat, Tiwari, Rajnarayan R., Rajnarayan R. Tiwari   +17 more
core   +1 more source

SeqFu: A Suite of Utilities for the Robust and Reproducible Manipulation of Sequence Files

Bioengineering, 2021
Sequence files formats (FASTA and FASTQ) are commonly used in bioinformatics, molecular biology and biochemistry. With the advent of next-generation sequencing (NGS) technologies, the number of FASTQ datasets produced and analyzed has grown exponentially,
Andrea Telatin, Piero Fariselli, Giovanni Birolo   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Gut Microbes, 2023
The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial ...
Henrik M. Roager, Catherine Stanton, Lindsay J. Hall   +2 more
doaj   +1 more source

Gut microbes and obesity [PDF]

Science, 2020
Metabolism A plethora of studies have uncovered correlations between gut microbiome composition and common disorders such as metabolic disease. The hope is that these correlations can be translated into therapies using mechanism-based approaches. An alternative approach is fecal microbiota transplantation (FMT), a procedure in which gut microbiota from
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Preterm gut microbiota and metabolome following discharge from intensive care [PDF]

, 2015
The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications to the preterm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and ...
Skeath, Tom, Perry, J. D. (John), Nelson, Andrew, Stewart, Christopher, Marrs, Emma, Embleton, Nicholas, Fernstad, Sara J., Fernstad, Sara Johansson, Berrington, Janet, Marrs, E. C. L. (Emma), Cummings, Stephen, Perry, John, Skeath, Thomas   +12 more
core   +1 more source