Results 91 to 100 of about 113,380 (310)

Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX

, 2010
Dynamic, multicompartment in vitro gastrointestinal simulators are often used to monitor gut microbial dynamics and activity. These reactors need to harbor a microbial community that is stable upon inoculation, colon region specific, and relevant to in ...
Marzorati, M., Sam Possemiers, Sahar El Aidy, Kleerebezem, M., Verstraete, Willy, Smidt, H., Marzorati, Massimo, Philippe Gérard, Rabot, S., Charlotte Grootaert, Verstraete, W., Aidy, S.F., El, Erwin Zoetendal, Hauke Smidt, Possemiers, Sam, Zoetendal, Erwin, Kleerebezem, Michiel, van der Wiele, T., Sylvie Rabot, Grootaert, C., Michiel Kleerebezem, Possemiers, S., Massimo Marzorati, Derrien, Muriel, Pieter Van den Abbeele, Tom Van de Wiele, Derrien, M.M.N., Rabot, Sylvie, Grootaert, Charlotte, van den Abbeele, P., Bruneau, A., Wiele, T., van der, Willy Verstraete, Zoetendal, E.G., El Aidy, Sahar, Gerard, Philippe, Abbeele, P., van den, Muriel Derrien, Smidt, Hauke, Van de Wiele, Tom, Gérard, P., Van den Abbeele, Pieter, Bruneau, Aurelia, El Aidy, S.F., Aurélia Bruneau   +44 more
core   +1 more source

Editorial: Gut physiology—microbes and inflammatory diseases

, 2023
Editorial on the Research Topic Gut physiology—microbes and inflammatory ...
Shubha Priyamvada, Akhtar, Suhail, Suhail Akhtar, Priyamvada, Shubha   +3 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Linking the edible plant microbiome and human gut microbiome

The edible plant microbiome, which includes microbes in raw-eaten plants, has been recently recognized as a vehicle delivering microbes to the gut. Fruits and vegetables can carry thousands to billions of microorganisms with diverse genetic capacities on
Schierstaedt, Jasper, Berg, Gabriele, Toledo, Gerardo V., Hyöty, Heikki, Adi Wicaksono, Wisnu   +4 more
core   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Gut Microbes Make for Fattier Fish [PDF]

Cell Host & Microbe, 2012
The mammalian gut microbiota influences both sides of the energy balance equation, salvaging energy from undigested nutrients and directing the host to accumulate adipose tissue. Semova et al. (2012) use zebrafish to demonstrate that the gut microbiota also promotes dietary lipid absorption, emphasizing the many host-microbial interactions contributing
Carmody, Rachel N, Turnbaugh, Peter J
openaire   +4 more sources

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Gut-Liver Axis and Sensing Microbes [PDF]

Digestive Diseases, 2010
‘Detoxification’ of gut-derived toxins and microbial products from gut-derived microbes is a major role of the liver. While the full repertoire of gut-derived microbial products that reach the liver in health and disease is yet to be explored, the levels of bacterial lipopolysaccharide (LPS), a component of Gram-negative bacteria, is increased in the ...
Gyongyi, Szabo, Shashi, Bala, Jan, Petrasek, Arijeet, Gattu   +3 more
openaire   +2 more sources

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source