Results 91 to 100 of about 114,048 (309)

Links between gut microbiome composition and fatty liver disease in a large population sample [PDF]

, 2022
Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample
Knight Rob, Vazquez-Baeza Yoshiki, Niiranen Teemu J, Jousilahti Pekka, Havulinna Aki S, Meric Guillaume, Lahti Leo, Åberg Fredrik, Salomaa Veikko, Jain Mohit, Liu Yang, Loomba Rohit, Valsta Liisa M, Männistö Ville, Inouye Michael, Tripathi Anupriya, Ruuskanen Matti O   +16 more
core   +1 more source

Improving causality in microbiome research: can human genetic epidemiology help? [version 3; peer review: 2 approved]

Wellcome Open Research, 2020
Evidence supports associations between human gut microbiome variation and multiple health outcomes and diseases. Despite compelling results from in vivo and in vitro models, few findings have been translated into an understanding of modifiable causal ...
Kaitlin H. Wade, Lindsay J. Hall
doaj   +1 more source

Microbes, immunoregulation, and the gut.

Gut, 2005
Two distinct, but rapidly converging, areas of research (the hygiene hypothesis and the study of probiotic/prebiotic effects) have emphasised the need to understand, and ultimately to manipulate, our physiological interactions with commensal flora, and with other transient but harmless organisms from the environment that affect immunoregulatory ...
Rook, GAW, Brunet, LR
openaire   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

The gut microbiota and mucosal homeostasis: Colonized at birth or at adulthood, does it matter? [PDF]

, 2013
The intimate interplay between the gut microbiota and the host may contribute to health and disease in the host. Experiments using conventionalized and conventionally raised animal models have illustrated the role of the intestinal microbiota in shaping ...
Kleerebezem, M., Tremaroli, Valentina,, Bäckhed, F., El Aidy, Sahar, El-Aidy, S.F., Tremaroli, V., Bäckhed, Fredrik,, Hooiveld, G.J.E.J., Hooiveld, Guido, Kleerebezem, Michiel   +9 more
core   +1 more source

Isolation and Cultivation of Human Gut Microorganisms: A Review [PDF]

, 2023
Microbial resources from the human gut may find use in various applications, such as empirical research on the microbiome, the development of probiotic products, and bacteriotherapy. Due to the development of “culturomics”, the number of pure
Qianqian Yang, Xiangfeng Wang, Yun Bai, Zhi Liu, Xuchun Wan   +4 more
core   +1 more source

Benchmark of Data Processing Methods and Machine Learning Models for Gut Microbiome-Based Diagnosis of Inflammatory Bowel Disease

Frontiers in Genetics, 2022
Patients with inflammatory bowel disease (IBD) wait months and undergo numerous invasive procedures between the initial appearance of symptoms and receiving a diagnosis.
Ryszard Kubinski, Jean-Yves Djamen-Kepaou, Timur Zhanabaev, Alex Hernandez-Garcia, Stefan Bauer, Falk Hildebrand, Falk Hildebrand, Tamas Korcsmaros, Tamas Korcsmaros, Sani Karam, Prévost Jantchou, Kamran Kafi, Ryan D. Martin   +12 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Gut microbes coordinate pulmonary immunity. [PDF]

Proc Natl Acad Sci U S A
Christodoulou C, Clarke TB.
europepmc   +4 more sources

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source