Results 51 to 60 of about 3,406 (140)

Long-term prednisone treatment causes fungal microbiota dysbiosis and alters the ecological interaction between gut mycobiome and bacteriome in rats

Frontiers in Microbiology, 2023
Glucocorticoids (GCs) are widely used in the treatment of immune-mediated diseases due to their anti-inflammatory and immunosuppressive effects. Prednisone is one of the most commonly used GCs.
Wenyan Li, Yun Shu, Jing Zhang, Mengmeng Wu, Guang-hua Zhu, Wen-yan Huang, Li Shen, Yulin Kang   +7 more
doaj   +1 more source

The Human Mycobiome: Colonization, Composition and the Role in Health and Disease

Journal of Fungi, 2022
The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth.
Paulina Belvoncikova, Petra Splichalova, Petra Videnska, Roman Gardlik   +3 more
doaj   +1 more source

Alterations in the gut mycobiome with coronary artery disease severity. [PDF]

EBioMedicine
Coronary artery disease (CAD) is a prevalent cardiovascular condition, and numerous studies have linked gut bacterial imbalance to CAD. However, the relationship of gut fungi, another essential component of the intestinal microbiota, with CAD remains poorly understood.In this cross-sectional study, we analyzed fecal samples from 132 participants, split
An K, Jia Y, Xie B, Gao J, Chen Y, Yuan W, Zhong J, Su P, Liu X.   +8 more
europepmc   +3 more sources

The gut-lung axis: the impact of the gut mycobiome on pulmonary diseases and infections. [PDF]

Oxf Open Immunol
Abstract The gastrointestinal tract contains a diverse microbiome consisting of bacteria, fungi, viruses and archaea. Although these microbes usually reside as commensal organisms, it is now well established that higher abundance of specific bacterial or fungal species, or loss of diversity in the microbiome can significantly affect ...
Sey EA, Warris A.
europepmc   +3 more sources

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Gut Fungal Microbiota Alterations in Pulmonary Arterial Hypertensive Rats

Biomedicines
The gut microbiome’s imbalance has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH), yet the contribution of the gut mycobiome remains largely unclear.
Yihang Chen, Liukun Meng, Wen Yuan, Zehan Gao, Xun Zhang, Boqia Xie, Jiawei Song, Jifeng Li, Jiuchang Zhong, Xiaoyan Liu   +9 more
doaj   +1 more source

The gut mycobiome: a novel player in chronic liver diseases [PDF]

Journal of Gastroenterology, 2020
AbstractThe human gut microbiome (bacteria, fungi, viruses, and archaea) is a complex and diverse ecosystem. It plays an important role in human health, but is involved in several intestinal and extraintestinal diseases. Most research to date has focused on the role of bacteria, while studies focusing on fungi (also referred to as “mycobiome” or ...
Jiang, Lu, Stärkel, Peter, Fan, Jian-Gao, Fouts, Derrick Eugene, Bacher, Petra, Schnabl, Bernd   +5 more
openaire   +4 more sources

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Roles of the gut virome and mycobiome in faecal microbiota transplantation

The Lancet Gastroenterology & Hepatology, 2022
Faecal microbiota transplantation (FMT) is an innovative approach to treat diseases that are associated with gut dysbiosis, by transferring a healthy stool microbiota to a recipient with disease. Beyond the bacteriome, the human gut also harbours diverse communities of viruses and fungi, collectively known as the virome and the mycobiome. The effect of
Lam, Siu, Bai, Xiaowu, Shkoporov, Andrey N., Park, Heekuk, Wu, Xiaojian, Lan, Ping, Zuo, Tao   +6 more
openaire   +3 more sources