Results 81 to 90 of about 3,406 (140)

Regulation of PD‐1PD‐L1 Immune Checkpoints by Gut Microbiota Metabolites and Their Clinical Translational Research: A Review

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
ABSTRACT Background Immune checkpoint inhibitors (ICIs) targeting the PD‐1/PD‐L1 pathway have revolutionized cancer immunotherapy, yet their clinical benefit is constrained by variable response rates and immune‐related adverse events. Aims This review systematically analyzes the molecular mechanisms by which key gut microbiota‐derived metabolites ...
Xuanyou Fang, Shuai Yuan, Weijian Mai
wiley   +1 more source

Methods for identification of the opportunistic gut mycobiome from colorectal adenocarcinoma biopsy tissues

MethodsX
Colorectal cancer poses a significant threat to global health, necessitating the development of effective early detection techniques. However, the potential of the fungal microbiome as a putative biomarker for the detection of colorectal adenocarcinoma ...
Aisyah Yunus, Norfilza Mohd Mokhtar, Raja Affendi Raja Ali, Siti Maryam Ahmad Kendong, Hajar Fauzan Ahmad   +4 more
doaj   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Altered gut mycobiome in patients with end-stage renal disease and its correlations with serum and fecal metabolomes

Journal of Translational Medicine
Background The relationship between the gut mycobiome and end-stage renal disease (ESRD) remains largely unexplored. Methods In this study, we compared the gut fungal populations of 223 ESRD patients and 69 healthy controls (HCs) based on shotgun ...
Yi Ren, Lei Chen, Ruochun Guo, Shiyang Ma, Shenghui Li, Yue Zhang, Hongli Jiang, Haitao Shi, Pan Zhang   +8 more
doaj   +1 more source

Metagenomics reveals unique gut mycobiome biomarkers in psoriasis. [PDF]

Skin Res Technol
Abstract Purpose In present, the diagnosis of psoriasis is mainly based on the patient's typical clinical manifestations, dermoscopy and skin biopsy, and unlike other immune diseases, psoriasis lacks specific indicators in the blood. Therefore, we are required to search novel biomarkers for the
Wang X, Sun J, Zhang X, Chen W, Cao J, Hu H.   +5 more
europepmc   +3 more sources

Gut mycobiome alterations in obesity in geographically different regions. [PDF]

Gut Microbes
The gut fungi play important roles in human health and are involved in energy metabolism. This study aimed to examine gut mycobiome composition in obese subjects in two geographically different regions in China and to identify specific gut fungi associated with obesity.
Zhan H, Wan Y, Sun Y, Xu Z, Zhang F, Yang K, Zhu W, Cheung CP, Tang W, Ng EK, Wong SK, Yeoh YK, Kl Chan F, Miao Y, Zuo T, Zeng Z, Ng SC.   +16 more
europepmc   +4 more sources

The gut microbiome and thermoregulatory response: Relevance of the microbiota in heat‐related illness?

Experimental Physiology, EarlyView.
Oliver R. Gibson
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Targeting the Gut–Brain Axis: Pharmacological Modulation of the Microbiome for Neurological and Behavioural Disorders in Companion Animals

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Gut microbiota communicate with the brain via the vagus nerve, SCFAs, GABA and serotonin, while maintaining gut barrier integrity and reducing neuroinflammation. In dogs, psychobiotics and prebiotics show moderate evidence, FMT shows very low evidence (case reports only), and dietary evidence is growing, but feline data remain limited. These adjunctive
Sakineh Khanamani Falahatipour, Motahareh Soltani   +1 more
wiley   +1 more source

An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients

Transplant Infectious Disease, Volume 28, Issue 4, July/August 2026.
ABSTRACT Invasive fungal infections (IFI) remain a significant infection‐related complication in solid organ transplant recipients (SOTRs), the incidence of which has not changed overtime. With a focus on studies and data published after 2019, this narrative review provides an update on the epidemiology and prevention of IFIs in SOTRs and highlights ...
Tina Marinelli, Shahid Husain
wiley   +1 more source