Expanding the Colorectal Cancer Biomarkers Based on the Human Gut Phageome [PDF]
Microbiology Spectrum, 2021 With the increasing prevalence of colorectal cancer (CRC), extending the present biomarkers for the diagnosis of colorectal cancer is crucial. Previous studies have highlighted the importance of bacteriophages in gastrointestinal diseases, suggesting the
Siyuan Shen +4 more
doaj +4 more sources
Gut phageome: challenges in research and impact on human microbiota [PDF]
Frontiers in MicrobiologyThe human gut microbiome plays a critical role in maintaining our health. Fluctuations in the diversity and structure of the gut microbiota have been implicated in the pathogenesis of several metabolic and inflammatory conditions.
Xiao Yu +7 more
doaj +4 more sources
Gut phageome in Mexican Americans: a population at high risk for metabolic dysfunction-associated steatotic liver disease and diabetes [PDF]
mSystemsMexican Americans are disproportionally affected by metabolic dysfunction-associated steatotic liver disease (MASLD), which often co-occurs with diabetes.
Suet-Ying Kwan +7 more
doaj +4 more sources
Eco-evolutionary dynamics of gut phageome in wild gibbons (Hoolock tianxing) with seasonal diet variations [PDF]
Nature CommunicationsIt has been extensively studied that the gut microbiome provides animals flexibility to adapt to food variability. Yet, how gut phageome responds to diet variation of wild animals remains unexplored.
Shao-Ming Gao +5 more
doaj +4 more sources
Characterizing the gut phageome and phage-borne antimicrobial resistance genes in pigs [PDF]
MicrobiomeBackground Mammalian intestine harbors a mass of phages that play important roles in maintaining gut microbial ecosystem and host health. Pig has become a common model for biomedical research and provides a large amount of meat for human consumption ...
Jun Hu +5 more
doaj +4 more sources
Engrafting gut bacteriophages have potential to modulate microbial metabolism in fecal microbiota transplantation [PDF]
MicrobiomeBackground Fecal microbiota transplantation (FMT) is widely used to treat severe infections and investigated for the treatment of complex diseases. The therapeutic efficacy of FMT is related to the successful engraftment of bacteriophages from healthy ...
Shuai Ji +6 more
doaj +2 more sources
Gut microbial and functional signatures in breast cancer: an integrated metagenomic and machine learning approach to non-invasive detection [PDF]
Frontiers in MicrobiologyIntroductionBreast cancer is associated with significant restructuring of the gut ecosystem. Gut microbial composition and function may influence cancer development and progression through immune modulation, metabolic regulation, and inflammation-related
Yalin Li +23 more
doaj +2 more sources
Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications. [PDF]
MicrobiologyopenThis study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Paul JK +6 more
europepmc +2 more sources
Gut phages and their interactions with bacterial and mammalian hosts [PDF]
Journal of BacteriologyThe mammalian gut microbiome is a dense and diverse community of microorganisms that reside in the distal gastrointestinal tract. In recent decades, the bacterial members of the gut microbiome have been the subject of intense research.
Marshall Godsil +3 more
doaj +2 more sources
Bacteriophages and their potential for treatment of metabolic diseases
Journal of DiabetesRecent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, metabolic dysfunction‐associated fatty liver disease, and cardiovascular diseases, including hypertension, stroke ...
Youpeng Deng +4 more
doaj +2 more sources