Results 31 to 40 of about 609 (113)

Healthy human gut phageome. [PDF]

Proc Natl Acad Sci U S A, 2016
Significance Humans need a stable, balanced gut microbiome (GM) to be healthy. The GM is influenced by bacteriophages that infect bacterial hosts. In this work, bacteriophages associated with the GM of healthy individuals were analyzed, and a healthy gut phageome (HGP) was discovered.
Manrique P, Bolduc B, Walk ST, van der Oost J, de Vos WM, Young MJ.   +5 more
europepmc   +6 more sources

Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission. [PDF]

J Clin Biochem Nutr
This study aimed to analyze the gut phageome in Japanese patients with ulcerative colitis (UC) in endoscopic remission. Fecal samples were collected from 35 UC patients and 22 healthy controls. The gut microbiome was analyzed using 16S rRNA amplicon sequencing, and the phageome was profiled through shotgun metagenomic sequencing.
Otsuki A, Inoue R, Imai T, Miura H, Nishida A, Inatomi O, Andoh A.   +6 more
europepmc   +5 more sources

Factors Affecting Variation of the Human Gut Phageome

Annual Review of Microbiology, 2023
The gut microbiome is a dense and metabolically active consortium of microorganisms and viruses located in the lower gastrointestinal tract of the human body. Bacteria and their viruses (phages) are the most abundant members of the gut microbiome. Investigating their biology and the interplay between the two is important if we are to understand their ...
Ciara A, Tobin, Colin, Hill, Andrey N, Shkoporov   +2 more
openaire   +2 more sources

Gut dsDNA virome shows diversity and richness alterations associated with childhood obesity and metabolic syndrome

iScience, 2021
Summary: Changes in the human gut microbiome are associated with obesity and metabolic syndrome, but the role of the gut virome in both diseases remains largely unknown. We characterized the gut dsDNA virome of 28 school-aged children with healthy normal-
Shirley Bikel, Gamaliel López-Leal, Fernanda Cornejo-Granados, Luigui Gallardo-Becerra, Rodrigo García-López, Filiberto Sánchez, Edgar Equihua-Medina, Juan Pablo Ochoa-Romo, Blanca Estela López-Contreras, Samuel Canizales-Quinteros, Abigail Hernández-Reyna, Alfredo Mendoza-Vargas, Adrian Ochoa-Leyva   +12 more
doaj   +1 more source

Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts. [PDF]

Sci Adv
Genetic variations are instrumental for unraveling phage evolution and deciphering their functional implications. Here, we explore the underlying fine-scale genetic variations in the gut phageome, especially structural variations (SVs). By using virome-enriched long-read metagenomic sequencing across 91 individuals, we identified a total of 14,438 ...
Lai S, Wang H, Bork P, Chen WH, Zhao XM.
europepmc   +4 more sources

A simple, reproducible and cost-effective procedure to analyse gut phageome: from phage isolation to bioinformatic approach. [PDF]

Sci Rep, 2019
AbstractThe microbiota of the human gut is a complex and rich community where bacteria and their viruses, the bacteriophages, are dominant. There are few studies on the phage community and no clear standard for isolating them, sequencing and analysing their genomes.
d'Humières C, Touchon M, Dion S, Cury J, Ghozlane A, Garcia-Garcera M, Bouchier C, Ma L, Denamur E, P C Rocha E.   +9 more
europepmc   +7 more sources

Long‐Read Sequencing Reveals Extensive DNA Methylations in Human Gut Phagenome Contributed by Prevalently Phage‐Encoded Methyltransferases

Advanced Science, Volume 10, Issue 25, September 5, 2023., 2023
A comprehensive survey using long‐read sequencing in 8848 gut phages across 104 fecal samples uncovers widespread DNA methylation (≈98%) and its potential benefits for phage viability. Intriguingly, over one‐third of the phages encode their own DNA methyltransferases, contributing to enhanced genome methylation.
Chuqing Sun, Jingchao Chen, Menglu Jin, Xueyang Zhao, Yun Li, Yanqi Dong, Na Gao, Zhi Liu, Peer Bork, Xing‐Ming Zhao, Wei‐Hua Chen   +10 more
wiley   +1 more source

Limitations of using 16S rRNA microbiome sequencing to predict oral squamous cell carcinoma

APMIS, Volume 131, Issue 6, Page 262-276, June 2023., 2023
A new era of next‐generation sequencing has changed our perception of the oral microbiome in health and disease, and with this there is a growing understanding that the oral microbiome is a contributing factor to oral squamous cell carcinoma (OSCC), a malignancy of the oral cavity. This study aimed to analyse the trends and relevant literature based on
Christopher Delaney, Chandra Lekha Ramalingam Veena, Mark C. Butcher, William McLean, Suror Mohamad Ahmad Shaban, Christopher J. Nile, Gordon Ramage   +6 more
wiley   +1 more source

Population and Spatial Features Impact the Gut Phageome-Bacteriome Structure and Interactions in a Mammal Species Living in Fragmented Habitats. [PDF]

Microb Ecol
Gao H, Ma X, Lu M, Wang Y, Liu H, Hu X, Nie Y.   +6 more
europepmc   +3 more sources

Microbiota‐related metabolites fueling the understanding of ischemic heart disease

iMeta, Volume 2, Issue 2, May 2023., 2023
Up‐to‐date knowledge of gut microbial taxa associated with ischemic heart disease (IHD). Microbial metabolites for mechanistic dissection of IHD pathology. Microbiome‐based therapies in IHD prevention and treatment.
Yong Fan, Jiajun Ying, Hongchuang Ma, Hanbin Cui   +3 more
wiley   +1 more source