Results 91 to 100 of about 119,881 (373)

Reduced Calcium Signaling Is Associated With Severe Graft-Versus-Host Disease: Results From Preclinical Models and From a Prospective EBMT Study

open access: yesFrontiers in Immunology, 2020
Despite its involvement in various immune functions, including the allogeneic activation of T-lymphocytes, the relevance of calcium (Ca2+) for GVHD pathobiology is largely unknown.
Katarina Riesner   +23 more
doaj   +1 more source

Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool. [PDF]

open access: yes, 2008
Mesenchymal stem cells (MSCs) from adult somatic tissues may differentiate in vitro and in vivo into multiple mesodermal tissues including bone, cartilage, adipose tissue, tendon, ligament or even muscle. MSCs preferentially home to damaged tissues where
García-Castro, J   +5 more
core  

Inflammasome effects in GvHD

open access: yesOncotarget, 2015
Myeloid-derived suppressor cells (MDSCs) are a naturally occurring immune regulatory population capable of suppressing inflammation, and are often associated with cancer, chronic infection and traumatic injury [1]. Growing interest in the application of MDSC therapeutically has been supported by preclinical studies in allo-graft rejection, autoimmunity
Brent H, Koehn   +2 more
openaire   +2 more sources

Atypical Wounds in Chronic Graft‐Versus‐Host Disease and Peripheral Arterial Disease Caused by Tyrosine Kinase Inhibitors

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT The term “atypical wounds” primarily refers to lesions with immunological or cancerous etiologies. However, these wounds can also be drug‐induced. We report about a 32‐year‐old man with a 6‐year history of chronic myelogenous leukemia (CML) and chronic graft‐versus‐host disease (cGvHD) following an HLA‐compatible allogeneic stem cell ...
E. K. Stuermer   +3 more
wiley   +1 more source

Cytokine Profiles in Various Graft-Versus-Host Disease Target Organs following Hematopoietic Stem Cell Transplantation

open access: yesCell Transplantation, 2012
Previous studies using genetic-deficient murine models suggest that different T-helper subsets may contribute to different types of tissue damages in graft-versus-host disease (GvHD). However, there is limited information available on the distribution of
Hsiu-Yu Lai   +3 more
doaj   +1 more source

Drug Hypersensitivity: A Correlation Study From Histopathology to Clinic

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Drug hypersensitivity (DH) can present with varied clinical and pathological manifestations that may mislead the referring physician. Available data regarding the concordance between pathological diagnosis and clinical findings in DH are scarce.
Olivier Philip   +5 more
wiley   +1 more source

On the crossroad between tolerance and posttransplant lymphoma. [PDF]

open access: yes, 1997
The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core   +1 more source

ACCELERATED CLEARANCE OF ANTI-THYMOCYTE GLOBULIN IN CHILDREN TRANSPLANTED FOR REFRACTORY CYTOPENIA OF CHILDHOOD VERSUS APLASTIC ANEMIA IS ASSOCIATED WITH INCREASED RISK OF GVHD [PDF]

open access: diamond, 2023
Eva Koopman-Coenen   +9 more
openalex   +1 more source

Delayed Time to First Skin Cancer Among Hematopoietic Stem Cell Transplant Recipients With Chronic Cutaneous Graft‐Versus‐Host Disease

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Hematopoietic stem cell transplant (HSCT) recipients face an increased risk of cutaneous malignancies. Chronic cutaneous graft‐versus‐host disease (cGVHD), specific to allogeneic HSCT (alloHSCT), has been proposed to further elevate this risk, though its impact on skin cancer latency and distribution remains unclear.
Amy J. Petty   +2 more
wiley   +1 more source

High fludarabine exposure and relationship with treatment-related mortality after nonmyeloablative hematopoietic cell transplantation. [PDF]

open access: yes, 2011
Despite its common use in nonmyeloablative preparative regimens, the pharmacokinetics of fludarabine are poorly characterized in hematopoietic cell transplantation (HCT) recipients and exposure-response relationships remain undefined.
Brunstein, CG   +9 more
core   +1 more source

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