Results 141 to 150 of about 119,881 (373)

Apoptosis kinetics of purified and PBMC‐associated lymphocytes after photopheresis‐like 8‐methoxypsolaren/UVA treatment

Photochemistry and Photobiology, EarlyView.
Extracorporeal photopheresis (ECP) induces apoptosis in circulating immune cells, but its kinetics vary slightly depending on the cell type. We compared the progression of apoptosis in PBMCs versus highly purified T cells exposed to 8‐methoxypsoralen and ultraviolet A.
Carlos Agustin Villegas‐Valverde, Imilla Casado Hernandez, Yandy Marx Castillo‐Aleman, Gisela Maria Suarez‐Formigo, Amar Riaz, Antonio Alfonso Bencomo‐Hernandez, Yendry Ventura‐Carmenate   +6 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants. [PDF]

, 2006
Studies in unrelated donor (UD) hematopoietic stem cell transplantations (HSCT) show an effect of the matching status of HLA-DPB1 on complications. We analyzed 423 UD-HSCT pairs. Most protocols included T-cell depletion (TCD).
Madrigal, JA, Marsh, SGE, Mayor, NP, Russell, NH, Shaw, BE   +4 more
core  

GVHD Prophylaxis

AbstractA potentially life-threatening complication of allo-HCT is graft-versus-host disease (GVHD), which occurs when T-cells from the recipient recognize host antigens on healthy tissues. Despite 50 years of history and over half a million procedures performed worldwide, GVHD remains a challenging issue that physicians are facing on a daily basis.
Jaap Jan Boelens, Francesca Bonifazi, Lars Klingen Gjærde, David Michonneau, Annalisa Ruggeri, Laura Saavedra, Gèrard Socié   +6 more
openaire   +1 more source

Venetoclax plus hypomethylating agents as effective bridge therapy to allogeneic stem cell transplant in relapsed/refractory acute myeloid leukaemia: A subanalysis of the AVALON study

British Journal of Haematology, EarlyView.
Elisabetta Petracci, Francesca Pavesi, Luca Castagna, Patrizia Zappasodi, Cristina Papayannidis, Calogero Vetro, Vincenzo Federico, Alessandro Cignetti, Erika Borlenghi, Nicola Fracchiolla, Luca Facchini, Luca Maurillo, Ernesta Audisio, Massimo Bernardi, Felicetto Ferrara, Francesco Lanza, Carmine Selleri, Ilenia Manfra, Claudio Cerchione, Jacopo Nanni, Andrea Davide Romagnoli, Giovanni Marconi, Chiara Zingaretti, Ivana Lotesoriere, Federica Gigli, Giovanni Martinelli, Elisabetta Todisco   +26 more
wiley   +1 more source

Preemptive Rituximab for Epstein–Barr Virus Reactivation after Hematopoietic Cell Transplantation: Necessary for All?

Transplant Infectious Disease, EarlyView.
A sudden increase in EBV DNAemia appears to be a better predictor of PTLD and EBV end‐organ disease than persistent and stable levels of EBV DNAemia. Most HCT recipients with EBV DNAemia did not require rituximab, and immunosuppression reduction was sufficient to control most episodes of EBV reactivation.
Anna Beatriz Coelho de Souza, Anderson João Simione, Ana Cláudia Ferrari dos Santos, Iago Colturato, Fernanda Rodrigues Barbieri, Juliana Ribeiro do Prado Moreno, Lilian Perílio Zanetti, Leila Cibele Serra de Oliveira, Erika Rodrigues Pontes Delattre, Juliana Silva Santos, Mair Pedro de Souza, Vergílio A. R. Colturato, Clarisse M. Machado   +12 more
wiley   +1 more source

Impact of methotrexate-dosing regimens for GVHD prophylaxis on clinical outcomes of HLA-matched allogeneic HSCT. [PDF]

Br J Haematol
Summary Severe graft‐versus‐host disease (GVHD) remains a major complication of allogeneic haematopoietic stem cell transplantation (allo‐HSCT), necessitating optimal immunosuppressive strategies. This retrospective study used data from the Japanese Transplant Registry Unified Management Program to compare three methotrexate (MTX)‐dosing regimens for ...
Suzuki T, Jo T, Yoshifuji K, Kondo T, Doki N, Kanda Y, Nishida T, Onishi Y, Asada N, Fukuda T, Sawa M, Hasegawa Y, Serizawa K, Ota S, Tanaka M, Yoshimitsu M, Atsuta Y, Kanda J.   +17 more
europepmc   +2 more sources

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud, Kerr, Matthew D, Mao, Angelo S, Mooney, David J, Raimondo, Theresa M, Scadden, David T, Shah, Nisarg J, Sharda, Azeem, Shih, Ting-Yu, Tager, Andrew M, Vrbanac, Vladimir D, Weaver, James C   +11 more
core   +1 more source

Immune‐related toxicity profile after haematopoietic stem cell transplantation in patients with B‐ALL given combination immunotherapy with rituximab, inotuzumab and blinatumomab

British Journal of Haematology, EarlyView.
Olayinka Okeleji, David McCall, Branko Cuglievan, Amber Gibson, Demetrios Petropoulos, Priti Tewari, Jeremy Connors, Irtiza N. Sheikh   +7 more
wiley   +1 more source

Stewardship of Molecular Diagnostics in Transplant Viral Infections

Transplant Infectious Disease, EarlyView.
ABSTRACT The transplant environment requires special considerations when testing for viral infections as immunosuppression results in atypical infection profiles. Microbes otherwise considered commensals or causing mild disease can lead to severe infections in transplant environments. Therefore, guidelines tend to recommend broader microbial testing in
Scott Sugden, David Reynoso, Reema Mathew, Michael Loeffelholz   +3 more
wiley   +1 more source