Results 11 to 20 of about 119,881 (373)

A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD

JCI Insight, 2021
Graft-versus-host disease (GVHD) is a pathological process caused by an exaggerated donor lymphocyte response to host antigens after allogeneic hematopoietic cell transplantation (allo-HCT).
M. Sofi, Yongxia Wu, Taylor Ticer, Steven Schutt, D. Bastian, Hee-Jin Choi, Linlu Tian, Corey Mealer, Chen Liu, C. Westwater, K. Armeson, A. Alekseyenko, Xue-Zhong Yu   +12 more
semanticscholar   +1 more source

Roles of the intestinal microbiota and microbial metabolites in acute GVHD

Experimental Hematology & Oncology, 2021
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most curative strategies for the treatment of many hematologic malignancies and diseases. However, acute graft-versus-host disease (GVHD) limits the success of allo-HSCT.
Dandan Lin, Bo Hu, Pengfei Li, Ye Zhao, Yang Xu, Depei Wu   +5 more
semanticscholar   +1 more source

Regulatory T Cells in GVHD Therapy

Frontiers in Immunology, 2021
Graft versus host disease (GVHD) is a common complication and the leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Wenwen Guo, X. Su, Mingyuan Wang, Mingzhe Han, Xiaoming Feng, E. Jiang   +5 more
semanticscholar   +1 more source

Non-classical manifestations of acute GVHD.

Blood, 2021
Acute graft-versus-host disease (GVHD) is a major life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). The classical target organs of acute GVHD include the intestines, liver, and skin.
R. Zeiser, T. Teshima
semanticscholar   +1 more source

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice.

Blood, 2020
The diversity of human microbiome heralds the difference of impact that gut microbial metabolites exert on allogenic graft-versus-host disease (GVHD), even though short-chain fatty acids and indole were demonstrated to reduce its severity. In this study,
Kunpeng Wu, Yan Yuan, Huihui Yu, Xin Dai, Shu Wang, Zhengxu Sun, Fen Wang, He Fei, Qiwang Lin, Hua Jiang, Tong Chen   +10 more
semanticscholar   +1 more source

Haploidentical BMT for severe aplastic anemia with intensive GVHD prophylaxis including posttransplant cyclophosphamide.

Blood Advances, 2020
Severe aplastic anemia (SAA) is a stem cell disorder often treated with bone marrow transplantation (BMT) to reconstitute hematopoiesis. Outcomes of related HLA-haploidentical (haplo) donors after reduced-intensity conditioning with intensive graft ...
A. Dezern, M. Zahurak, H. Symons, K. Cooke, G. Rosner, D. Gladstone, C. Huff, L. Swinnen, Philip H. Imus, I. Borrello, N. Wagner-Johnston, R. Ambinder, L. Luznik, J. Bolaños-Meade, E. Fuchs, Richard J. Jones, R. Brodsky   +16 more
semanticscholar   +1 more source

Late-onset acute GVHD: clues for endothelial GVHD [PDF]

Blood, 2016
Late acute (LA) graft-versus-host disease (GVHD) has recently been added to the clinical spectrum of GVHD. In this issue of Blood, Holtan et al (and the Chronic GVHD Consortium) studied LA GVHD in a large prospective cohort and describe its link with circulating angiogenic factors ...
Gérard, Socié, David, Michonneau
openaire   +2 more sources

Oral Graft-Versus-Host Disease: A Pictorial Review and a Guide for Dental Practitioners

International Dental Journal, 2021
Introduction: Graft-versus-host disease (GVHD) is a complication of haematopoietic stem cell transplantation (HSCT). GVHD may also develop following solid transplants or blood transfusions if white blood cells are transferred.
Sharon Elad, Omar Aljitawi, Yehuda Zadik
doaj   +1 more source

Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia

OncoImmunology, 2020
Graft-versus-host disease (GvHD) remains a significant impediment to allogeneic hematopoietic cell transplantation (HCT) success, necessitating studies focused on alleviating GvHD, while preserving the graft-versus-leukemia (GvL) effect.
Jessica Stokes, Emely A. Hoffman, Megan S. Molina, Nicole Kummet, Richard J. Simpson, Yi Zeng, Emmanuel Katsanis   +6 more
doaj   +1 more source

Transcriptome analysis in acute gastrointestinal graft-versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease

Haematologica, 2023
We performed transcriptomic analyses on freshly frozen (n=21) and paraffin-embedded (n=35) gastrointestinal (GI) biopsies from children with and without acute acute GI graft-versus-host disease (GvHD) to study differential gene expressions.
Pooja Khandelwal, Dana T Lounder, Allison Bartlett, Yael Haberman, Anil G. Jegga, Sudhir Ghandikota, Jane Koo, Nathan Luebbering, Daniel Leino, Sheyar Abdullah, Michaela Loveless, Phillip Minar, Kelly Lake, Bridget Litts, Rebekah Karns, Adam S. Nelson, Lee A. Denson, Stella M. Davies   +17 more
doaj   +1 more source