Results 11 to 20 of about 76,191 (305)

In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]

Frontiers in Immunology 2014. 5:529, 2014
Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
Batalo, Michael, Buck, Gregory A., Griffith, Phil, Hess, Michael L., Jameson-Lee, Max, Khalid, Haniya, Koparde, Vishal, Manjili, Masoud H., Neale, Michael C., Roberts, Catherine H., Sampson, Juliana K., Scalora, Allison F., Serrano, Myrna G., Sheth, Nihar U., Toor, Amir A.   +14 more
arxiv   +5 more sources

Clinical Outcomes and Treatment Strategies of Adult Transplant‐Associated Thrombotic Microangiopathy: External Validation of Harmonizing Definitions and High‐Risk Criteria [PDF]

American Journal of Hematology, Volume 100, Issue 5, Page 830-839, May 2025.
ABSTRACT Transplant‐associated thrombotic microangiopathy (TA‐TMA) is an endothelial dysfunction syndrome observed after allogeneic hematopoietic cell transplant (alloHCT). Our aim was to externally validate the impact of high‐risk features on the clinical outcomes of adult patients meeting the updated TA‐TMA harmonizing criteria. Between 2005 and 2022,
Aldo A. Acosta‐Medina, Meera Sridharan, Ronald S. Go, Ann M. Moyer, Nelson Leung, Maria Alice V. Willrich, Robert Wolf, Rabee Kassis, Almothana Manasrah, Mira A. Kohorst, Urshila Durani, Aasiya Matin, Mehrdad Hefazi, Saad J. Kenderian, Abhishek A. Mangaonkar, Mithun V. Shah, Mark R. Litzow, William J. Hogan, David Dingli, Hassan B. Alkhateeb   +19 more
wiley   +2 more sources

The Impact of Health‐Promoting Lifestyle Behaviors on Gut Microbiota in Survivors of Hematological Cancer: A Scoping Review [PDF]

Cancer Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Purpose This scoping review aims to explore the relationship between health‐promoting lifestyle behaviors and gut microbiota in survivors of hematological cancers, including leukemia, lymphoma, and multiple myeloma. Given the rising incidence of these malignancies and the associated treatment challenges, understanding how lifestyle factors ...
Elham Samami, Angela Starkweather, Debra Lynch Kelly, Debra Lyon   +3 more
wiley   +2 more sources

Constrictive Pericarditis as a Rare Manifestation of Graft‐Versus‐Host Disease: A Case Report [PDF]

Clinical Case Reports, Volume 13, Issue 5, May 2025.
ABSTRACT Graft‐versus‐host disease (GVHD) is a serious inflammatory complication that can arise after allogeneic transplantation, characterized by donor T‐cells attacking the recipient's tissues. While cardiac complications are infrequent, they are more commonly observed in cases of chronic GVHD and may manifest as pericardial effusion, cardiac ...
Alireza Arzhangzadeh, Mahmood Zamirian, Ladan Nasermoadeli, Asma Mousavi, Salma Nozhat, Roozbeh Narimani Javid, Sasan Shafiei, Salar Azadnik, Shayan Shojaei   +8 more
wiley   +2 more sources

Extracellular vesicles: a new frontier in diagnosing and treating graft-versus-host disease after allogeneic hematopoietic cell transplantation [PDF]

Journal of Nanobiotechnology
Graft-versus-host disease (GvHD) is a prevalent complication following allogeneic hematopoietic stem cell transplantation (HSCT) and is characterized by relatively high morbidity and mortality rates.
Peipei Wu, Zhangfei Wang, Yongping Sun, Zhixiang Cheng, Min Wang, Baolong Wang   +5 more
doaj   +2 more sources

Hematopoietic Stem Cell Transplantation Outcomes in Diamond–Blackfan Anemia Patients Based on Myeloablative Conditioning Regimen With or Without Total Body Irradiation: A Systematic Review and Meta‐Analysis [PDF]

eJHaem, Volume 6, Issue 3, June 2025.
ABSTRACT Diamond–Blackfan anemia (DBA) is a rare, congenital bone marrow failure syndrome characterized by hypoplastic anemia. Earliest descriptions of this disease date back to 1936, and since then, a plethora of treatment strategies have been used to control or treat the disease.
Parsa Fathi, Leila Jafari, Afshin Fathi, Ayat Ahmadi, Yalda Karamlou, Maryam Behfar, Amir Ali Hamidieh   +6 more
wiley   +2 more sources

Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia

OncoImmunology, 2020
Graft-versus-host disease (GvHD) remains a significant impediment to allogeneic hematopoietic cell transplantation (HCT) success, necessitating studies focused on alleviating GvHD, while preserving the graft-versus-leukemia (GvL) effect.
Jessica Stokes, Emely A. Hoffman, Megan S. Molina, Nicole Kummet, Richard J. Simpson, Yi Zeng, Emmanuel Katsanis   +6 more
doaj   +1 more source

Impact of the histologic grade of acute gastrointestinal graft-versus-host disease on outcomes in pediatric patients treated with allogeneic hematopoietic stem cell transplantation

Frontiers in Medicine, 2023
IntroductionAcute gastrointestinal graft-versus-host disease (GVHD) is a common life-threatening complication after hematopoietic stem cell transplantation (HCT).
Eun Sil Kim, Eun Sil Kim, Yiyoung Kwon, Yiyoung Kwon, Yon Ho Choe, Mi Jin Kim, Keon Hee Yoo, Keon Hee Yoo, Keon Hee Yoo   +8 more
doaj   +1 more source

Transcriptome analysis in acute gastrointestinal graft-versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease

Haematologica, 2023
We performed transcriptomic analyses on freshly frozen (n=21) and paraffin-embedded (n=35) gastrointestinal (GI) biopsies from children with and without acute acute GI graft-versus-host disease (GvHD) to study differential gene expressions.
Pooja Khandelwal, Dana T Lounder, Allison Bartlett, Yael Haberman, Anil G. Jegga, Sudhir Ghandikota, Jane Koo, Nathan Luebbering, Daniel Leino, Sheyar Abdullah, Michaela Loveless, Phillip Minar, Kelly Lake, Bridget Litts, Rebekah Karns, Adam S. Nelson, Lee A. Denson, Stella M. Davies   +17 more
doaj   +1 more source

Regulatory T Cells in GVHD Therapy [PDF]

Frontiers in Immunology, 2021
Graftversushost disease (GVHD) is a common complication and the leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Pharmacological immunosuppression used in GVHD prophylaxis and treatment lacks specificity and can increase the likelihood of infection and relapse.
Xiaoming Feng, Ming-Yang Wang, Wen-Wen Guo, Mingzhe Han, Xiu-Hua Su, Erlie Jiang   +5 more
openaire   +4 more sources