Results 41 to 50 of about 119,881 (373)

Stem Cell Transplantation As A Dynamical System: Are Clinical Outcomes Deterministic? [PDF]

, 2014
Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune
Buck, Gregory A, Chung, Harold, Clark, William, Jameson-Lee, Max, Kobulnicky, Jared D, Koparde, Vishal, Manjili, Masoud H, McCarty, John, Meier, Jeremy, Neale, Michael C, Roberts, Catherine H, Sabo, Roy T, Salman, Salman, Scalora, Allison, Serrano, Myrna, Sheth, Nihar, Toor, Amir A   +16 more
core   +3 more sources

Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis. [PDF]

PLoS ONE, 2009
BACKGROUND:The clinical and histologic appearance of fibrosis in cutaneous lesions in chronic graft-versus -host disease (c-GVHD) resembles the appearance of fibrosis in scleroderma (SSc).
Jo Nadine Fleming, Howard M Shulman, Richard A Nash, Pamela Y Johnson, Thomas N Wight, Allen Gown, Stephen M Schwartz   +6 more
doaj   +1 more source

Post-transplantation cyclophosphamide reduces the incidence of acute graft-versus-host disease in patients with acute myeloid leukemia/myelodysplastic syndromes who receive immune checkpoint inhibitors after allogeneic hematopoietic stem cell transplantation

Journal for ImmunoTherapy of Cancer, 2021
Background Immune checkpoint inhibitors (ICIs) are being used after allogeneic hematopoietic stem cell transplantation (alloHCT) to reverse immune dysfunction.
Maro Ohanian, Farhad Ravandi, Maria E Suarez-Almazor, Adi Diab, Noha Abdel-Wahab, Houssein Safa, Ala Abudayyeh, Marina Konopleva, Stephen Gruschkus, Chantal Saberian, May Daher, Richard Champlin, Kaysia Ludford, Gheath Al-Atrash, Guillermo Garcia-Manero, Naval Daver, Hind Rafei, Jacinth Joseph, Gabriela Rondon, Laura Whited, Faisal Fa'ak, Cristina Knape, Mahran Shoukier, Megan Marcotulli, Alison M Gulbis, Betul Oran, Uday R Popat, Rotesh Mehta, Amin M Alousi   +28 more
doaj   +1 more source

Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease: Alterations in Skin Barrier Function and Related Molecules

Chinese Medical Journal, 2017
Background: Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation. Skin barrier disruption could induce thymic stromal lymphopoietin (TSLP) expression, and the expression of TSLP was increased in lesions of ...
Kun Li, Zhang-Lei Mu, Xue Chen, Guang-Dong Wen, Yan Zhao, Jian-Zhong Zhang   +5 more
doaj   +1 more source

MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD.

Blood, 2018
Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid immunosuppression. Clinical response after 1 week of therapy often guides further treatment decisions, but long-term outcomes vary widely among centers, and more accurate ...
Hannah Major-Monfried, A. Renteria, A. Pawarode, P. Reddy, F. Ayuk, E. Holler, Y. Efebera, W. Hogan, M. Wölfl, M. Qayed, E. Hexner, K. Wudhikarn, R. Ordemann, R. Young, Jay Shah, Matthew J. Hartwell, M. Chaudhry, Mina Aziz, Aaron M. Etra, G. Yanik, N. Kröger, D. Weber, Yi-Bin Chen, R. Nakamura, W. Rösler, C. Kitko, Andrew C. Harris, M. Pulsipher, R. Reshef, Steven Kowalyk, George Morales, Ivan Torres, U. Özbek, J. Ferrara, J. Levine   +34 more
semanticscholar   +1 more source

Long-term outcome after a treosulfan-based conditioning regimen for patients with acute myeloid leukemia: A report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation [PDF]

, 2017
BACKGROUND: Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for patients with acute myeloid leukemia (AML). However, post-HCT relapse and regimen-related toxicity remain significant barriers to long-term survival.
Al Mumma, Baron, Boztug, Boztug, Bredeson, Burroughs, Carreras, Casper, Casper, Cieri, Copelan, Dalle, Danylesko, Fichtner, Galaup, Glowka, Gupta, Gyurkocza, Kroger, Kroger, Majhail, Meinhardt, Munkelt, Nagler, Nagler, Palmer, Pel, Richardson, Rizzo, Savani, Savani, Scheulen, Schmidmaier, Schmitt, Sengsayadeth, Sengsayadeth, Shimoni, Shimoni, Slatter, ten Brink, Wachowiak, Williams   +41 more
core   +1 more source

Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation. [PDF]

, 2020
Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients, and treatment options are limited by toxicities. CSJ148 is a combination of two anti-HCMV human monoclonal antibodies (LJP538 and LJP539) that bind to and inhibit ...
Akard, Luke, Chemaly, Roy, Christoph, Sandra, Gerbitz, Armin, Hiemenz, John, Holler, Ernst, Hwang, William YK, Jang, Junho, Koh, Liang Piu, Lee, Dong-Gun, Logan, Aaron C, Long, Gwynn, Maertens, Johan, Mielke, Stephan, Pertel, Peter, Ramachandra, Sangana, Segal, Florencia, Smith, Kristin, Tang, Jih-Luh, Wang, Po-Nan, Winkler, Julia, Yeh, Su-Peng, Yeo, Adeline   +22 more
core   +3 more sources

Pathophysiology of GvHD and Other HSCT-Related Major Complications

Frontiers in Immunology, 2017
For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD).
Sakhila Ghimire, D. Weber, Emily R. Mavin, X. Wang, A. Dickinson, E. Holler   +5 more
semanticscholar   +1 more source

Scleral Lens and Prosthetic Replacement of the Ocular Surface Ecosystem Utilization in Ocular Graft-versus-Host Disease: A Survey Study

Clinical Ophthalmology, 2021
Shannon M Bligdon,1 Bradley A Colarusso,2 Allen Y Ganjei,3 Alan Kwok,4 Zhonghui Katie Luo,2 Daniel Brocks4 1Ajax Eye Care, Ajax, ON, Canada; 2Massachusetts Eye and Ear, Boston, MA, USA; 3Drexel University College of Medicine, Philadelphia, PA, USA ...
Bligdon SM, Colarusso BA, Ganjei AY, Kwok A, Luo ZK, Brocks D   +5 more
doaj  

Rare cells predict GVHD [PDF]

Blood, 2012
Although natural killer (NK) T cells are present in about 1 in a 1000 T cells contained in hematopoietic cell transplants used for treatment of leukemia and lymphoma, their number is the dominant predictor of acute graft-versus-host disease (GVHD) in transplant patients according to the paper by Chaidos et al in this issue of Blood ...
Samuel, Strober, Robert, Lowsky
openaire   +2 more sources