Results 71 to 80 of about 119,881 (373)

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Journal of Experimental Medicine, 2016
Activation of TNFR2 with a novel agonist expands T reg cells in vivo and protects allo-HCT recipients from acute GvHD while sparing antilymphoma and antiinfectious properties of transplanted donor T cells.
Martin Chopra, Marlene Biehl, Tim Steinfatt, A. Brandl, J. Kums, J. Amich, M. Vaeth, Janina Kuen, R. Holtappels, J. Podlech, A. Mottok, S. Kraus, Ana-Laura Jordán-Garrote, Carina A. Bäuerlein, C. Brede, Eliana Ribechini, A. Fick, A. Seher, Johannes Polz, Katja J Ottmüller, J. Baker, Hidekazu Nishikii, M. Ritz, K. Mattenheimer, Stefanie Schwinn, Thorsten Winter, Viktoria Schäfer, S. Krappmann, H. Einsele, T. Müller, M. Reddehase, M. Lutz, D. Männel, F. Berberich-Siebelt, H. Wajant, A. Beilhack   +35 more
semanticscholar   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease

Frontiers in Immunology, 2019
Data from both animal models and humans have demonstrated that effector memory T cells (TEM) and central memory T cells (TCM) from unprimed donors have decreased ability to induce graft-vs-host disease (GVHD).
Wei Huang, Wenjian Mo, Wenjian Mo, Jieling Jiang, Jieling Jiang, Nelson J. Chao, Nelson J. Chao, Benny J. Chen, Benny J. Chen   +8 more
doaj   +1 more source

Measurement of oral chronic GVHD: results from the Chronic GVHD Consortium [PDF]

Bone Marrow Transplantation, 2013
Oral chronic GVHD (cGVHD) is a serious complication of alloSCT. Scales and instruments to measure oral cGVHD activity and severity have not been prospectively validated. The objective of this study was to describe the characteristics of oral cGVHD and determine the measures most sensitive to change.
N, Treister, X, Chai, B, Kurland, S, Pavletic, D, Weisdorf, J, Pidala, J, Palmer, P, Martin, Y, Inamoto, M, Arora, M, Flowers, D, Jacobsohn, M, Jagasia, S, Arai, S J, Lee, C, Cutler   +15 more
openaire   +2 more sources

Post-transplantation cyclophosphamide combined with tacrolimus and low-dose post-engraftment anti-thymoglobulin as GVHD prophylaxis for patients undergoing peripheral blood stem cell transplantation from haploidentical family donor: A single center analysis [PDF]

, 2023
Wenhui Gao, Jia-yan Zhu, Lining Wang, Ming Wan, Xuan Wang, Raynier Devillier, Jieling Jiang, Didier Blaise, Jiong Hu   +8 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Novel Insights Into the Mechanism of GVHD-Induced Tissue Damage

Frontiers in Immunology, 2021
Prophylaxis for and treatment of graft-versus-host disease (GVHD) are essential for successful allogeneic hematopoietic stem cell transplantation (allo-SCT) and mainly consist of immunosuppressants such as calcineurin inhibitors.
Takahide Ara, Daigo Hashimoto
doaj   +1 more source

Intestinal transplantation under tacrolimus monotherapy after perioperative lymphoid depletion with rabbit anti-thymocyte globulin (thymoglobulin®) [PDF]

, 2005
Modifications in the timing and dosage of immunosuppression can ameliorate the morbidity and mortality that has prevented widespread use of intestinal transplantation (ITx) in children.
Abu-Elmagd, K, Bond, GJ, Macedo, C, Mazariegos, GV, Murase, N, Peters, J, Reyes, J, Sindhi, R, Starzl, TE   +8 more
core   +1 more source

Current approaches to prevent and treat GVHD after allogeneic stem cell transplantation.

Hematology. American Society of Hematology. Education Program, 2018
Allogeneic hematopoietic cell transplantation is a potentially curative therapy for many malignant and nonmalignant hematologic diseases. Graft-versus-host disease (GVHD) is a common complication after transplantation and remains a major cause of ...
B. Hamilton
semanticscholar   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source