Results 71 to 80 of about 76,191 (305)
Frontiers in Immunology, 2019 Data from both animal models and humans have demonstrated that effector memory T cells (TEM) and central memory T cells (TCM) from unprimed donors have decreased ability to induce graft-vs-host disease (GVHD).
Wei Huang +8 more
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AbstractA potentially life-threatening complication of allo-HCT is graft-versus-host disease (GVHD), which occurs when T-cells from the recipient recognize host antigens on healthy tissues. Despite 50 years of history and over half a million procedures performed worldwide, GVHD remains a challenging issue that physicians are facing on a daily basis.
Jaap Jan Boelens +6 more
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Biologic markers of chronic GVHD [PDF]
Bone Marrow Transplantation, 2013 Biologic markers of chronic GVHD may provide insight into the pathogenesis of the syndrome, identify molecular targets for novel interventions, and facilitate advances in clinical management. Despite extensive work performed to date largely focused on prediction and diagnosis of the syndrome, little synthesis of findings and validation of promising ...
Stephanie J. Lee +3 more
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Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1171-1174, May 2025.Japan's conditional/time‐limited early approval program, initiated in 2014, aimed to advance regenerative medicine by expediting market access. However, the withdrawal of autologous skeletal myoblast sheets (Heartsheet) due to ineffectiveness raises concerns about the balance between rapid approval and scientific integrity.
Hayase Hakariya +3 more
wiley +1 more source
Frontiers in Oncology, 2014 Graft-versus-host disease (GVHD) is still one of the major causes of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (HSCT). In the pathogenesis of acute GVHD, it has been established that donor-derived T cells activated in
Shigeo eFuji +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an evidence based- cellular immunotherapy for hematological malignancies. Immune reactions not only promote graft-versus-tumor effects that kill hematological malignant cells but also ...
Hideaki Fujiwara
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Hematology, 2007 Abstract Acute graft-versus-host disease (GVHD) is the most frequent, morbid complication following allogeneic hematopoietic stem cell transplantation (HSCT). Its clinical toxicity, requirement for intensive immunosup-pressive management, and associated infections lead to the greatest risks of nonrelapse mortality in HSCT recipients.
openaire +3 more sources
Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1413-1426, May 2025.Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo‐HCT) is heterogeneous and influenced by various patient‐ and transplantation‐related factors, associated with poor prognoses for poor graft function (PGF) and isolated thrombocytopenia.
Katharina M. Götz +23 more
wiley +1 more source
Cell Transplantation, 2012 Previous studies using genetic-deficient murine models suggest that different T-helper subsets may contribute to different types of tissue damages in graft-versus-host disease (GvHD). However, there is limited information available on the distribution of
Hsiu-Yu Lai +3 more
doaj +1 more source
Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease [PDF]
arXiv, 2016 The association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n=50; matched related donor (MRD), n=27) underwent whole exome sequencing to identify single ...
arxiv