Results 81 to 90 of about 119,881 (373)
New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity. [PDF]
, 2017 Interleukin-15 (IL-15) is a potent cytokine that increases CD8+ T and NK cell numbers and function in experimental models. However, obstacles remain in using IL-15 therapeutically, specifically its low potency and short in vivo half-life.
Alpdogan, Onder +8 more
core +3 more sources
Blood, 2015 In this issue of Blood , results from [Veenstra et al][1] highlight an important role of the B7-superfamily member B7-H3 (CD276) in allogeneic bone marrow transplantation.[1][2] ![Figure][3] (A) (Top) Transfer of allogeneic T cells into B7-H3–deficient animals leads to an increased ...
openaire +2 more sources
A critical role for donor‐derived IL‐22 in cutaneous chronic GVHD
American Journal of Transplantation, 2018 Graft‐versus‐host disease (GVHD) is the major cause of nonrelapse morbidity and mortality after allogeneic stem cell transplantation (allo‐SCT).
Kate H. Gartlan +21 more
semanticscholar +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.
JCI Insight, 2018 Graft-versus-host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HCT). The tyrosine kinase SYK contributes to both acute and chronic GVHD development, making it an attractive target for GVHD prevention.
J. Poe +13 more
semanticscholar +1 more source
Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia. [PDF]
, 2017 We developed a haploidentical transplantation protocol with post-transplant cyclophosphamide (CY) for in vivo T-cell depletion (TCD) using a novel adapted-dosing schedule (25 mg/kg on days +3 and +4) for Fanconi anemia (FA).
Bonfim, C +8 more
core +2 more sources
Arthritis &Rheumatology, Accepted Article.Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong +13 more
wiley +1 more source
Frontiers in Oncology, 2014 Graft-versus-host disease (GVHD) is still one of the major causes of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (HSCT). In the pathogenesis of acute GVHD, it has been established that donor-derived T cells activated in
Shigeo eFuji +3 more
doaj +1 more source
Blood, 2018 In this issue of Blood , Swimm et al report that the tryptophan metabolite indole that is produced by the intestinal microbiome limits graft-versus-host disease (GVHD). In mouse models of GVHD, they found that indoles act via type I interferons (IFNs) to limit chemotherapy- and radiotherapy-induced damage to the intestinal epithelium ...
openaire +3 more sources
JPGN Reports, EarlyView.Abstract Pediatric patients with CD19+ acute lymphoblastic leukemia (ALL) undergoing chimeric antigen receptor T‐cell (CAR‐T) therapy frequently experience gastrointestinal (GI) complications. A retrospective study analyzed 13 patients (median age: 8 years) treated between January 2020 and January 2024.
Judith Raya Muñoz +8 more
wiley +1 more source