Results 281 to 290 of about 283,327 (339)

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

Sensory Neuroscience, EarlyView.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan, Avanthika Nityanand, Anjali Pandit, Vaishnavi Gururajan   +3 more
wiley   +1 more source

Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health. [PDF]

Nat Commun
Ye C, Dou C, Liu D, Kong L, Chen M, Xu M, Xu Y, Li M, Zhao Z, Zheng J, Lu J, Chen Y, Ning G, Wang W, Bi Y, Wang T.   +15 more
europepmc   +1 more source

Depression as a causal factor in obstructive sleep apnea: An analysis based on the NHANES 2005–2008

Sleep Research, EarlyView.
Abstract Background Depression and obstructive sleep apnea (OSA) have complex and incompletely understood pathophysiological links. Our study used National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2008 to elucidate their associations.
Guo‐qiang Song, Hua‐man Wu, Yi‐meng Duan, Guo‐qiang Hu   +3 more
wiley   +1 more source

Genome-Wide Association Study Reveals Novel QTNs and Candidate Genes Implicated in Resistance to Northern Corn Leaf Blight in Maize (<i>Zea mays</i> L.). [PDF]

Int J Mol Sci
Shetty U, Sowmya MS, Lohithaswa HC, Mallikarjuna MG, Jadesha G, Nayaka SC.   +5 more
europepmc   +1 more source

Investigating the shared genetic architecture between obstructive sleep apnea and sleep‐related traits

Sleep Research, EarlyView.
Abstract Background Despite a strong link between obstructive sleep apnea (OSA) and sleep traits, the shared genetic architecture remains unclear. This study aims to explore the shared genetic basis and bidirectional causal between OSA and sleep traits.
Sizhi Ai, Hengyu Zhang, Jiaqi Liu, Zhen Song, Zaiming Liao, Guohua Li, Shujuan Yin, Binhe Yu, Sheng Guo, Ruizhi Zhang, Caihui Cha, Yingjun Zheng   +11 more
wiley   +1 more source

Mean and variance heterogeneity loci impact kernel compositional traits in maize. [PDF]

Plant Genome
Ismail YMA, Mujjabi C, Olatoye MO, Gray S, Lipka AE, Bohn MO.   +5 more
europepmc   +1 more source

Integration of QTL mapping and GWAS reveals the complicated genetic architecture of chemical composition traits in tobacco leaves [PDF]

Asad Ullah, Zhijun Tong, Muhammad Rizwan Kamran, Feng Lin, Tianneng Zhu, Muhammad Shahzad, Umaira, Xuejun Chen, Bingguang Xiao, Haiming Xu   +9 more
openalex   +1 more source

Development of a prognostic nomogram and genetic insights for prostate cancer patients with secondary primary malignancies: A SEER retrospective cohort study and Mendelian randomization analysis

UroPrecision, EarlyView.
Abstract Background Prostate cancer (PCa) patients are at risk of developing second primary malignancies (SPMs), which can significantly shorten their survival. Understanding the risk of SPMs and associated factors is crucial to the optimization of patient follow‐up.
Qi Zhang, Lufan Liang, Ziyu Liu, Ziyang Yang, Jiahao Cheng, Xuan Li, Yueting Huang, Weisi Chen, Jiazhen Yin, Ligong Chen, Zhang Cao, Di Gu   +11 more
wiley   +1 more source

Causal relationship between plasma homocysteine levels and colorectal cancer: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Ru X, Wu L, Guo Y, Shen Y.
europepmc   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source