Results 261 to 270 of about 174,316 (315)

Trans-ethnic estimation and implications of genetic impact on continuous glycemic profiles. [PDF]

Cell Discov
Yu EY, Ren HY, Liang X, Xi Y, Shuai M, Miao Z, Xu F, Zhang K, Shen L, Xia H, Schram MT, van Greevenbroek M, de Galan BE, van der Kallen CJH, Linden DEJ, Blokland GAM, Arts ICW, Berendschot TTJM, Yan Y, Fu Y, Wesselius A, Chen Y, Zheng JS.   +22 more
europepmc   +1 more source

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua, Xinyi Wu, Tahani Al Kindi, Bulent O. Yildiz, Aya Mousa, Loyal Pattuwage, Helena Teede, Anju E. Joham, Chau Thien Tay   +8 more
wiley   +1 more source

Genetic dissection of protein content in cowpea using custom-made NIRS equations and GWAS as a model for nutritional breeding and undergraduate research training. [PDF]

G3 (Bethesda)
Akinmade H, Ben-Israel S, Ryan A, Johnson C, Tharayil A, Arias RO, Ulbricht Ferreira RC, Fernandes C, Boz Z, Rios E.   +9 more
europepmc   +1 more source

TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β‐Catenin Signalling Pathway in Obstructive Nephropathy

Cell Proliferation, EarlyView.
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei, Zixia Li, Gengyu Du, Ting Chen, Min Yang, Zhen Yuan, Yidan Zheng, Xiang Yan   +7 more
wiley   +1 more source

Genetic architecture of angular leaf spot resistance in cultivated strawberry shaped by epistasis and genotype-by-environment interactions. [PDF]

Plant Genome
Torgeman S, Pincot DDA, Bjornson M, Famula RA, Skillin P, Krill-Brown A, Feldmann MJ.   +6 more
europepmc   +1 more source

Unveiling the BMI Risk Threshold for Osteoarthritis: Multi‐Database Causal and Nonlinear Evidence

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective To characterize the nonlinear relationship between BMI and osteoarthritis (OA), and to identify BMI thresholds that inform precise prevention strategies. Methods This multi‐database study integrated Global burden of disease 2021, National Health and Nutrition Examination Survey 2007–2018, and Genome‐Wide Association Studies.
Shaohong Yu, Li Zeng, Lei Yang, Yangjiang Ou, Chenglin Yang, Xiaoru Lin, Jingyi Shao, Qing Guan, Guobo Li, Xiuquan Lin   +9 more
wiley   +1 more source

Tractor workflow: a scalable Nextflow framework for local ancestry-aware genome-wide association studies. [PDF]

Bioinformatics
Shah NN, Tan T, Honorato-Mauer J, Lin YS, Maihofer AX, Zai CC, PGC-PTSD ancestry working group , Santoro M, Nievergelt CM, Atkinson EG.   +9 more
europepmc   +1 more source

Multivariate GWAS reveals shared genetic basis of common oral diseases. [PDF]

Front Genet
Ma X, Zheng X.
europepmc   +1 more source

The illusion of polygenicity in pool-seq genetic mapping studies: insufficient power can mask simple genetic architectures. [PDF]

Genetics
Long AD, Hanson KM, Macdonald SJ.
europepmc   +1 more source

Direct and indirect genetic effects of birthweight predisposition on child DNA methylation at birth. [PDF]

Epigenetics
Creasey N, Frach L, Isaevska E, Felix JF, Cecil C, Pingault JB, Neumann A.   +6 more
europepmc   +1 more source