Results 71 to 80 of about 491,703 (337)

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
wiley   +1 more source

Surgery Advances in Gynecologic Tumors: The Evolution and Outcomes of Robotic Surgery for Gynecologic Cancers in a Tertiary Center

Current Oncology
The integration of innovation into routine clinical practice is faced with many challenges. In 2007, we received the mandate to evaluate how the introduction of a robotic program in gynecologic oncology affected patient-centered care by studying its ...
David Knigin, Yoav Brezinov, Shannon Salvador, Susie Lau, Walter H. Gotlieb   +4 more
doaj   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source

Gastroscope Application in Difficult Colonoscopy: An Effective Alternative for Patients with Gynecologic Oncology

Clinical and Experimental Obstetrics & Gynecology
Background: Whole-colon examination is crucial for patients with gynecologic oncology, which somehow presents challenges in some cases. This study is aiming to investigate the effectiveness of gastroscope applied in difficult colonoscopy among such ...
Linna Luo, Wei Qiao, Xinxin Huang, Yin Li, Jianjun Li, Wencheng Tan, Longjun He   +6 more
doaj   +1 more source

Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.

Journal of Clinical Oncology, 2019
PURPOSE To evaluate the impact of two different intraperitoneal (IP) chemotherapy regimens on progression-free survival (PFS) among women with newly diagnosed advanced ovarian carcinoma. METHODS Eligible patients were randomly assigned to six cycles of
Joan L. Walker, M. Brady, L. Wenzel, G. Fleming, Helen Q. Huang, P. DiSilvestro, K. Fujiwara, D. Alberts, Wenxin Zheng, K. Tewari, D. Cohn, M. Powell, L. Van Le, S. Davidson, H. Gray, P. Rose, C. Aghajanian, T. Myers, A. Alvarez Secord, S. Rubin, R. Mannel   +20 more
semanticscholar   +1 more source

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy

Advanced Science, EarlyView.
In ovarian tumors with high CMTM4 expression, exosomes transfer CMTM4 to macrophages, upregulating ICAM1 and promoting M2 polarization via p65 nuclear translocation. This suppresses immunity by increasing PD‐1 and Tregs while reducing CD8+ T cells.
Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han   +12 more
wiley   +1 more source

The perceptions of gynecologic oncology fellows on readiness for subspecialty training following OB/GYNRESIDENCY

Gynecologic Oncology Reports, 2019
A recent survey of fellowship program directors (PD) within gynecologic oncology (GO) noted concerns regarding the abilities of incoming fellows. The objective of this study was to evaluate the perceptions of current and former fellows in gynecologic ...
Renata R. Urban, Amin A. Ramzan, David W. Doo, Jeanelle Sheeder, Saketh R. Guntupalli   +4 more
doaj  

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

Evaluation of intra- and post-operative outcomes to compare robot-assisted surgery and conventional laparoscopy for gynecologic oncology

Asian Journal of Surgery, 2020
Summary: Objective: To compare robot-assisted surgery and conventional laparoscopy for gynecologic oncology regarding intra- and post-operative outcomes. Methods: A retrospective study was performed on consecutive patients with gynecologic oncology from
Liu-Li Wang, Pei-Jing Yan, Liang Yao, Rong Liu, Fan Hou, Xiao-Hong Chen, Liang-liang Han, Li-Yuan Xu, Hui Xu, Jing Li, Tian-Kang Guo, Ke-Hu Yang, Hai-Lin Wang   +12 more
doaj  

Gynecologic Oncology

Journal of Obstetrics and Gynaecology Research, 2020
Jargalsaikhan Badarch, MD, Yanjinsuren Darmaa, MD, Amarzaya Lkhagvasuren, MD, Tsendsuren Dashzevge, MD, Uils Altankhuyag, MD, Tegshjargal Sereenedorj, MD Mongolian National University of Medical Sciences, Unimed Hospital, Enkh-Torokhui Clinic ...
Jargalsaikhan Badarch, Yanjinsuren Darmaa, Amarzaya Lkhagvasuren, Tsendsuren, Dashzevge, Uils Altankhuyag, Tegshjargal Sereenedorj, Maria Cenizal-Santos, Angelica Anne A. Chua, N. LeoFrancis, Aquilizan   +10 more
semanticscholar   +1 more source