Results 111 to 120 of about 507,240 (308)

GSLR Drives Lung Adenocarcinoma as a Critical Regulator of Energy Homeostasis Through Creatine Kinase B Activation

Advanced Science, EarlyView.
This study identifies the glucose/glutamine sensitive lncRNA GSLR as a driver of lung adenocarcinoma progression. Nutrient restriction reduces chromatin accessibility at the GSLR locus and blocks CTCF‐mediated transcriptional regulation. GSLR directly interacts with DHX9 and recruits it to the CKB promoter, arresting R‐loop accumulation and promoting ...
Xinyi Qian, Juze Yang, Jiayi Ren, Xiaowei Mao, Jia Li, Tengfei Sun, Liangliang Dong, Enguo Chen, Yan Lu, Pengyuan Liu   +9 more
wiley   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Education level is associated with the occurrence and timing of hysterectomy: A cohort study of Canadian women

Acta Obstetricia et Gynecologica Scandinavica
Introduction Hysterectomy is a common surgery with discernible practice variations that could be influenced by socioeconomic factors. We examined the association between level of educational attainment and the occurrence and timing of hysterectomy in ...
Erin A. Brennand, Natalie V. Scime, Beili Huang, Pauline McDonagh Hull   +3 more
doaj   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Next‐generation monitoring in obstetrics: Assessing the accuracy of non‐piezo portable ultrasound technology

Acta Obstetricia et Gynecologica Scandinavica
Introduction The emergence of handheld ultrasound devices capable of connecting to cell phones or tablets heralds a significant advancement in medical technology, particularly within the field of obstetrics.
Ruben Plöger, Charlotte Behning, Adeline Walter, Jorge Jimenez Cruz, Ulrich Gembruch, Brigitte Strizek, Florian Recker   +6 more
doaj   +1 more source

Natural orifice transluminal endoscopic surgery (NOTES) in gynecology

, 2019
Natural Orifice Transluminal Endoscopic Surgery (NOTES) is an emerging field in minimally invasive surgery. NOTES can be performed via a variety of approaches, including through the stomach, esophagus, bladder, and rectum, but the majority of cases have ...
Walters, Mark D., Jallad, Karl
core   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Robotic surgery in gynecology

Кубанский научный медицинский вестник, 2016
The article describes the use of a da Vinci-assisted (DV) gynecological surgery. DV is the biggest technological development of the recent decades. Currently, over 4000 robotic surgical systems in 54 developed countries and 25 robotic surgical systems in
A. A. Popov, K. V. Atroshenko, B. A. Slobodyanuyk, G. Z. Ashurova, S. I. Zingan   +4 more
doaj  

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Opieka ginekologiczna z perspektywy pacjentek ze szczególnym uwzględnieniem osób w wieku 12-25 lat, LBTQ oraz z niepełnosprawnościami

Journal of Education, Health and Sport, 2015
Wonatowska Patrycja, Skonieczna Joanna. Opieka ginekologiczna z perspektywy pacjentek ze szczególnym uwzględnieniem osób w wieku 12-25 lat, LBTQ oraz z niepełnosprawnościami = Gynecological care from the perspective of patients with special focus on ...
Patrycja Wonatowska, Joanna Skonieczna
doaj