Results 31 to 40 of about 175,293 (159)
Advanced Science, EarlyView.A quantitative CTC RNA assay is developed by incorporating multi‐antibody‐based CTC isolation and specific mRNA quantification using RT‐ddPCR. The NSCLC CTC ScoreD demonstrates high accuracy for early‐stage NSCLC detection, significantly outperforming serum CEA. NSCLC CTC ScoreM exhibits a more accurate early‐warning of responses to different therapies
Xiaoyu Wang +14 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source
SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway
Advanced Science, EarlyView.Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang +9 more
wiley +1 more source
Light‐Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression
Angewandte Chemie, EarlyView.A photo‐triggered CRISPR/Cas12a machinery for gene editing is introduced. The machinery is applied for endogenous DNA methyltransferase 1 (DNMT1) gene editing and for in vitro disruption of the hepatocyte growth factor (HGF) gene. The machinery is used for in vivo knockout and disruption of the HGF gene in HepG2 tumors, resulting in effective apoptosis
Hong Liu +7 more
wiley +2 more sources
Advanced Science, EarlyView.Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu +12 more
wiley +1 more source
Advanced Science, EarlyView.Gestational environmental stress activates ER‐phagy by increasing placental Rtn3l mRNA N6‐methyladenosine modification, further inhibiting placental estradiol synthesis and contributing to fetal testicular dysplasia. This study demonstrates the early prevention and treatment of adult male infertility from the perspective of fetal‐derived diseases ...
Ye‐Xin Luo +17 more
wiley +1 more source
Women’s Health educational opportunities at the University of Iowa’s Department of Obstetrics and Gynecology [PDF]
, 2012 The Department of Obstetrics and Gynecology’s educational programs span a continuum of learners from undergraduate premedical students to continuing education for practicing providers in Iowa and nearby states. The Department of Obstetrics and Gynecology
Elson, Marygrace
core +2 more sources
FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity
Advanced Science, EarlyView.Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li +11 more
wiley +1 more source
, 2019 Dr. Nina N. Moreira is an Associate in the Maternal Fetal Medicine Division of Obstetrics and Gynecology at the University of Iowa Hospitals and Clinics. She received a BS in Molecular, Cellular and Developmental Biology from Yale University.
core +5 more sources
Synapsis: Philadelphia Campus (1961) [PDF]
, 1960 This yearbook includes the Atlas Club, Iota Tau Sigma, ITS, (ΙΤΣ), Lambda Omicron Gamma, LOG, (ΛΟΓ), Phi Sigma Gamma, PSG, (ΦΣΓ), Christian Osteopathic Society, Hillel, Hillel Society, Catholic Guild, Undergraduate Academy of Applied Osteopathy, Society ...
Philadelphia College of Osteopathy
core +4 more sources