Results 11 to 20 of about 2,823 (117)
Effective therapeutic targeting of CTNNB1-mutant hepatoblastoma with WNTinib. [PDF]
Mol OncolWNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Balaseviciute U +17 more
europepmc +2 more sources
No evidence of association between inherited thrombophilia and increased risk of liver fibrosis
United European Gastroenterology Journal, Volume 11, Issue 10, Page 1010-1020, December 2023., 2023 Abstract Background Preliminary evidence suggests that inherited hypercoagulable disorders can lead to an increased risk of significant liver fibrosis. Objective We aimed to investigate the prevalence of significant fibrosis in patients with inherited thrombophilia, assessed by using liver stiffness (LS), and to compare this prevalence to that found in
Iranzu Ezcurra +18 more
wiley +1 more source
Liver International, Volume 43, Issue 12, Page 2776-2793, December 2023., 2023 Abstract Background & Aims The class I‐ phosphatidylinositol‐3 kinases (PI3Ks) signalling is dysregulated in almost all human cancers whereas the isoform‐specific roles remain poorly investigated. We reported that the isoform δ (PI3Kδ) regulated epithelial cell polarity and plasticity and recent developments have heightened its role in hepatocellular ...
Vanessa Bou Malham +16 more
wiley +1 more source
Exploring the landscape of steatotic liver disease in the general US population
Liver International, Volume 43, Issue 11, Page 2425-2433, November 2023., 2023 Abstract Background and Objective The aim of the present study is to explore the epidemiologic impact of the definition of steatotic liver disease (SLD) proposed by a multi‐society (American Association for the Study of the Liver‐the European Association for the Study of Liver Diseases‐Asociación Latinoamericana para el Estudio del Hígado) Delphi ...
Stefano Ciardullo +3 more
wiley +1 more source
C(spn)−X (n=1–3) Bond Activation by Palladium
Chemistry – A European Journal, Volume 28, Issue 26, May 6, 2022., 2022 Less is more! Our quantum chemical analyses reveal that the activity of palladium catalysts towards C−X bond activation increases along ethane, ethylene, acetylene because the steric repulsion between catalyst and substrate is relieved as the number of substituents around the carbon atom goes down.
Thomas Hansen +6 more
wiley +1 more source
Metallodrugs: an approach against invasion and metastasis in cancer treatment
FEBS Open Bio, Volume 12, Issue 5, Page 880-899, May 2022., 2022 In this review, we examine the use of metallodrugs for cancer treatment, focussing on the advances in this type of therapy and the importance of these compounds, with emphasis on Pt, Ru, Au, Zn, and Cu as antimetastatic agents. In addition, we discuss the different mechanisms of action by which metallodrugs exert their therapeutic effects.
Mauricio M. González‐Ballesteros +2 more
wiley +1 more source
Development of a Hepatoprotective Herbal Drug from Turnera diffusa
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 The incidence of liver diseases, such as nonalcoholic fatty liver disease and drug‐induced liver injury, continues to rise and is one of the leading causes of acute hepatitis. Current trends suggest that these types of conditions will increase in the coming years.
Cecilia Delgado-Montemayor +7 more
wiley +1 more source
Eficacia de la rifaximina en los diferentes escenarios clínicos de la encefalopatía hepática
Revista de Gastroenterología de México, 2020 Resumen: La encefalopatía hepática (EH) es una complicación frecuente en pacientes con cirrosis hepática y se asocia a una alta tasa de mortalidad.
C.E. Coronel-Castillo +4 more
doaj +1 more source
Annals of Hepatology, 2022 Introduction and objectives: Decompensated cirrhosis is defined by the onset of complications and is associated with immune dysfunction. This is the result of two processes: systemic inflammation and damage made by the immune system. Our objective was to
B. Tijerina-Soto +4 more
doaj +1 more source
IGFBP-1 TO 7 AS BIOMARKERS IN STAGES OF LIVER FIBROSIS DURING VIRAL HEPATITIS C
Annals of Hepatology, 2022 Introduction and Objectives: Diagnosis of liver disease (LD) is essential for the treatment and management of patients. The use of non-invasive methodologies is necessary despite the availability of direct-acting antivirals, some reports has been showed ...
M. Martínez-Castillo +5 more
doaj +1 more source