Results 81 to 90 of about 5,328,680 (285)

Optimal Regularity Properties of the Generalized Sobolev Spaces

Journal of Function Spaces and Applications, 2013
We prove optimal embeddings of the generalized Sobolev spaces , where is a rearrangement invariant function space, into the generalized Hölder-Zygmund space generated by a function space .
G. E. Karadzhov, Qaisar Mehmood
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Solvability of a Quadratic Integral Equation of Fredholm Type with Supremum in Hölder Spaces

, 2014
Using the classical Schauder fixed point theorem, we prove the existence of solutions of a quadratic integral equation of Fredholm type with supremum in the space of functions satisfying the Holder condition.
J. Mena, R. Nalepa, K. Sadarangani
semanticscholar   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Superposition operator problems of Hölder-Lipschitz spaces

Demonstratio Mathematica
Let ff be a function defined on the real line, and Tf{T}_{f} be the corresponding superposition operator which maps hh to Tf(h){T}_{f}\left(h), i.e., Tf(h)=f∘h{T}_{f}\left(h)=f\circ h. In this article, the sufficient and necessary conditions such that Tf{
Niu Yeli, Wang Heping
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

On maximal regularity for the Cauchy-Dirichlet mixed parabolic problem with fractional time derivative

Bruno Pini Mathematical Analysis Seminar, 2018
In this seminar we illustrate some results of maximal regularity for the Cauchy-Dirichlet mixed problem, with a fractional time derivative of Caputo type in spaces of continuous and Hölder continuous functions.
Davide Guidetti
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Anisotropic Two-Microlocal Spaces and Regularity

Journal of Function Spaces, 2014
We define D-u-anisotropic two-microlocal spaces by decay conditions on anisotropic wavelet coefficients on any D-u-anisotropic wavelet basis of L2(Rd). We prove that these spaces allow the characterizing of pointwise anisotropic Hölder regularity.
Mourad Ben Slimane
doaj   +1 more source