Results 91 to 100 of about 1,265,454 (291)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Experimental observation and edge characteristics of EDA H-mode on the HL-3 tokamak
Nuclear FusionThe enhanced ${D_\alpha }$ (EDA) H-mode features high energy confinement together with the absence of edge localized modes (ELMs) and impurity accumulation, making it highly attractive for fusion reactors. The EDA H-mode has been observed recently in the
Anshu Liang +21 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Preliminary efforts toward a compact D–D neutron generator based on a helicon plasma source [PDF]
AIP AdvancesThis study attempted to apply a helicon plasma source to a compact Deuterium–Deuterium (D–D) neutron generator, ultimately achieving a maximum neutron yield of up to 1.27 × 109 n/s with stable operation for over 1 h.
Mengmeng Li +8 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Limiter H-mode experiments on TFTR [PDF]
, 1991 Limiter H-modes with centrally peaked density profiles have been obtained in TFTR using a highly conditioned graphite limiter. The transition to these centrally peaked H-modes takes place from the supershot to the H-mode rather than the usual L- to H-mode transition observed on other tokamaks.
Bush +31 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Density pedestal prediction model for tokamak plasmas
Nuclear FusionA model for the pedestal density prediction based on neutral penetration combined with pedestal transport is presented. The model is tested against a pedestal database of JET-ILW Type I ELMy H-modes showing good agreement over a wide range of parameters ...
S. Saarelma +20 more
doaj +1 more source
First Results of the Implementation of the Doppler Backscattering Diagnostic for the Investigation of the Transition to H-Mode in the Spherical Tokamak Globus-M2. [PDF]
Sensors (Basel), 2023 Ponomarenko A +7 more
europepmc +1 more source