Results 101 to 110 of about 1,278,723 (261)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The impact of tungsten and tungsten transport on H-mode plasmas, experiments and modeling

Nuclear Fusion
Tungsten has been identified and shown to have several very good properties which are necessarily required by the plasma facing material of a magnetic fusion reactor.
C. Angioni
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Helium plasma operations on ASDEX Upgrade and JET in support of the non-nuclear phases of ITER

Nuclear Fusion
For its initial operational phase, ITER has until recently considered using non-nuclear hydrogen (H) or helium (He) plasmas to keep nuclear activation at low levels.
A. Hakola, M. Balden, M. Baruzzo, R. Bisson, S. Brezinsek, T. Dittmar, D. Douai, M. Dunne, L. Garzotti, M. Groth, R. Henriques, L. Horvath, I. Jepu, E. Joffrin, A. Kappatou, D. Keeling, K. Krieger, B. Labit, M. Lennholm, J. Likonen, A. Loarte, P. Lomas, C. Lowry, M. Maslov, D. Matveev, R.A. Pitts, U. Plank, M. Rasinski, D. Ryan, S. Saarelma, S. Silburn, E.R. Solano, W. Suttrop, T. Tala, E. Tsitrone, N. Vianello, T. Wauters, A. Widdowson, M. Wischmeier, the EUROfusion Tokamak Exploitation Team, the ASDEX Upgrade Team, JET Contributors   +41 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Optimised ‘hybrid’ scenario H-mode plasmas for W radiation control in JET with the Be/W wall

Nuclear Fusion
Screening of high- Z (W) impurities from the confined plasma by the temperature gradient at the plasma periphery of fusion-grade H-mode plasmas was demonstrated for the first time in JET with the Be/W wall (Field et al 2023 Nucl.
A.R. Field, C. Angioni, I.S. Carvalho, P. Carvalho, C.D. Challis, A. Chomiczewska, I.H. Coffey, D. Fajardo, L. Frasinetti, J.M. Fontdecaba, C. Giroud, J. Hobirk, A. Kappatou, D. Keeling, D.B. King, D. Kos, B. Labit, E. Lerche, E. Litherland-Smith, S. Menmuir, C. Olde, H. Sun, N. Vianello, S. Wiesen, JET Contributors, the EUROfusion Tokamak Exploitation Team   +25 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Experimental validation of non-uniformity effect of the radial electric field on the edge transport barrier formation in JT-60U H-mode plasmas. [PDF]

Sci Rep, 2016
Kamiya K, Itoh K, Itoh SI.
europepmc   +1 more source

Physical Origin of H-Mode

The high confinement mode (H-mode), the most important operation mode for the nuclear fusion reactor, has been studied for 42 years, but the transition mechanism has not been unanimously agreed so far. Four decades of H-mode experiments revealed many features of heating power threshold (Pth) for the low to high confinement (L-H) transition, where Pth ...
openaire   +2 more sources