Results 121 to 130 of about 14,643,969 (266)

1.06 µm picosecond pulsed, normal dispersion pumping for generating efficient broadband infrared supercontinuum in meter-length single-mode tellurite holey fiber with high Raman gain coefficient

, 2011
We investigate efficient broadband infrared supercontinuum generation in meter-length single-mode small-core tellurite holey fiber. The fiber is pumped by 1.06µm picosecond pulses in the normal dispersion region.
Shi, Jindan, Feng, Xian, Teh, Peh Siong, Chen, Kangkang, Horak, Peter, Ibsen, Morten, Richardson, David J., Alam, Shaif-ul, Loh, Wei H.   +8 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ELMy-H mode as Limit Cycle and Transient Responses of H-modes in Tokamaks

, 1993
"A model of Edge Localized Modes (ELMS) in tokamaks is presented. The model of the L/H transition, which is based on the electric field bifurcation, is extended to Include the temporal evolution and the spatial structure.
"Itoh, S.-I., Itoh, K., Fukuyama, A."
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

H-MODE THRESHOLD AND DYNAMICS IN THE NATIONAL SPHERICAL TORUS EXPERIMENT

, 2018
Edge parameters play a critical role in high confinement mode (H-mode) access, which is a key component of discharge optimization in present day toroidal confinement experiments and the design of next generation devices.
Kaye, SM, Roney, PG, Taylor, G, Bell, MG, Medley, S, Kubota, S, Bush, CE, Synakowski, EJ, LeBlanc, BP, Stutman, D, Kaita, R, Paoletti, F, Maqueda, RJ, Davis, WM, Ono, M, Roquemore, AL, Peng, YKM, Wilgen, JB, Mueller, D, Maingi, R, Fredrickson, ED, Mastrovito, D, Soukhanovskii, VA, Swain, DW, Lee, KC, Kugel, HW, Paul, SJ, Johnson, DW, Raman, R, Zweben, SJ, Park, H, Sabbagh, SA, Gates, DA, Skinner, CH, Boedo, J, Bell, RE, Menard, JE   +36 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Development of a two-term model for the confinement in ELMy H-modes using the global confinement and pedestal databases

The overlap of pulses in the pedestal database and the global H-mode confinement database has been increased. This has resulted in a new improved combined dataset with core and pedestal energy data.
Thomsen, K., Martin, Y., Cordey, J.G.
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source