Results 141 to 150 of about 14,643,969 (266)

Helium plasma operations on ASDEX Upgrade and JET in support of the non-nuclear phases of ITER

Nuclear Fusion
For its initial operational phase, ITER has until recently considered using non-nuclear hydrogen (H) or helium (He) plasmas to keep nuclear activation at low levels.
A. Hakola, M. Balden, M. Baruzzo, R. Bisson, S. Brezinsek, T. Dittmar, D. Douai, M. Dunne, L. Garzotti, M. Groth, R. Henriques, L. Horvath, I. Jepu, E. Joffrin, A. Kappatou, D. Keeling, K. Krieger, B. Labit, M. Lennholm, J. Likonen, A. Loarte, P. Lomas, C. Lowry, M. Maslov, D. Matveev, R.A. Pitts, U. Plank, M. Rasinski, D. Ryan, S. Saarelma, S. Silburn, E.R. Solano, W. Suttrop, T. Tala, E. Tsitrone, N. Vianello, T. Wauters, A. Widdowson, M. Wischmeier, the EUROfusion Tokamak Exploitation Team, the ASDEX Upgrade Team, JET Contributors   +41 more
doaj   +1 more source

Ohmic H-modes in the TCV tokamak

CRPPSPCPaper presented at the IAEA Technical Committee Meeting on H-mode Physics ...
Weisen, H., Dutch, M., Hofmann, F.
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Optimised ‘hybrid’ scenario H-mode plasmas for W radiation control in JET with the Be/W wall

Nuclear Fusion
Screening of high- Z (W) impurities from the confined plasma by the temperature gradient at the plasma periphery of fusion-grade H-mode plasmas was demonstrated for the first time in JET with the Be/W wall (Field et al 2023 Nucl.
A.R. Field, C. Angioni, I.S. Carvalho, P. Carvalho, C.D. Challis, A. Chomiczewska, I.H. Coffey, D. Fajardo, L. Frasinetti, J.M. Fontdecaba, C. Giroud, J. Hobirk, A. Kappatou, D. Keeling, D.B. King, D. Kos, B. Labit, E. Lerche, E. Litherland-Smith, S. Menmuir, C. Olde, H. Sun, N. Vianello, S. Wiesen, JET Contributors, the EUROfusion Tokamak Exploitation Team   +25 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Robust confinement state classification with uncertainty quantification through ensembled data-driven methods

Nuclear Fusion
Maximizing fusion performance in tokamaks relies on high energy confinement, often achieved through distinct operating regimes. The automated labeling of these confinement states is crucial to enable large-scale analyses or for real-time control ...
Yoeri Poels, Cristina Venturini, Alessandro Pau, Olivier Sauter, Vlado Menkovski, the TCV Team, the WPTE Team   +6 more
doaj   +1 more source

Experimental validation of non-uniformity effect of the radial electric field on the edge transport barrier formation in JT-60U H-mode plasmas. [PDF]

Sci Rep, 2016
Kamiya K, Itoh K, Itoh SI.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source