Results 141 to 150 of about 19,217,453 (333)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Non-linear MHD investigations of high-confinement regimes without type-I ELMs in ASDEX Upgrade and JT-60SA

Nuclear Fusion
Large edge localised modes (ELMs) would cause an unacceptable reduction of material lifetime in future large tokamaks due to the significant amount of energy expelled from the magnetically confined region towards the plasma facing components.
A. Cathey, M. Hoelzl, L. Meier, M.G. Dunne, G.T.A. Huijsmans, L. Gil, G.F. Harrer, N. Aiba, D.J. Cruz-Zabala, K. Lackner, S.J.P. Pamela, E. Viezzer, E. Wolfrum, S. Günter, the JOREK Team, the ASDEX Upgrade Team, and the EUROfusion WPTE Team   +16 more
doaj   +1 more source

Correlation of the tokamak H-mode density limit with ballooning stability at the separatrix

, 2018
T. Eich, R. Goldston, A. Kallenbach, B. Sieglin, H. Sun, J. Contributors   +5 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The impact of tungsten and tungsten transport on H-mode plasmas, experiments and modeling

Nuclear Fusion
Tungsten has been identified and shown to have several very good properties which are necessarily required by the plasma facing material of a magnetic fusion reactor.
C. Angioni
doaj   +1 more source

Physical Origin of H-Mode

The high confinement mode (H-mode), the most important operation mode for the nuclear fusion reactor, has been studied for 42 years, but the transition mechanism has not been unanimously agreed so far. Four decades of H-mode experiments revealed many features of heating power threshold (Pth) for the low to high confinement (L-H) transition, where Pth ...
openaire   +2 more sources

Parameter dependences of the separatrix density in nitrogen seeded ASDEX Upgrade H-mode discharges

, 2018
A. Kallenbach, H. Sun, T. Eich, D. Carralero, J. Hobirk, A. Scarabosio, M. Siccinio   +6 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Helium plasma operations on ASDEX Upgrade and JET in support of the non-nuclear phases of ITER

Nuclear Fusion
For its initial operational phase, ITER has until recently considered using non-nuclear hydrogen (H) or helium (He) plasmas to keep nuclear activation at low levels.
A. Hakola, M. Balden, M. Baruzzo, R. Bisson, S. Brezinsek, T. Dittmar, D. Douai, M. Dunne, L. Garzotti, M. Groth, R. Henriques, L. Horvath, I. Jepu, E. Joffrin, A. Kappatou, D. Keeling, K. Krieger, B. Labit, M. Lennholm, J. Likonen, A. Loarte, P. Lomas, C. Lowry, M. Maslov, D. Matveev, R.A. Pitts, U. Plank, M. Rasinski, D. Ryan, S. Saarelma, S. Silburn, E.R. Solano, W. Suttrop, T. Tala, E. Tsitrone, N. Vianello, T. Wauters, A. Widdowson, M. Wischmeier, the EUROfusion Tokamak Exploitation Team, the ASDEX Upgrade Team, JET Contributors   +41 more
doaj   +1 more source