Results 61 to 70 of about 1,276,201 (259)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Gyrokinetic simulation of eigenmode GAM in EAST H-mode plasma

Nuclear Fusion
Gyrokinetic simulations based on the Gyrokinetic Toroidal Code are conducted to investigate the geodesic acoustic mode (GAM) physics in the pedestal of EAST H-mode discharge $\#$ 74036 (Zhou et al 2018 Nucl. Fusion 58 106009).
Dongxiao Zhang, Chao Dong, Chu Zhou, Adi Liu, Yifei Ouyang, Jian Bao, Pengfei Liu, Jintao Cao, Wenlu Zhang, Zhihong Lin, Ding Li, Shouxin Wang, Hailin Zhao, Haiqing Liu   +13 more
doaj   +1 more source

H-mode accelerating structures with permanent-magnet quadrupole beam focusing

Physical Review Special Topics. Accelerators and Beams, 2012
We have developed high-efficiency normal-conducting rf accelerating structures by combining H-mode resonator cavities and a transverse beam focusing by permanent-magnet quadrupoles (PMQ), for beam velocities in the range of a few percent of the speed of ...
S. S. Kurennoy, L. J. Rybarcyk, J. F. O’Hara, E. R. Olivas, T. P. Wangler   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Experimental observation and edge characteristics of EDA H-mode on the HL-3 tokamak

Nuclear Fusion
The enhanced ${D_\alpha }$ (EDA) H-mode features high energy confinement together with the absence of edge localized modes (ELMs) and impurity accumulation, making it highly attractive for fusion reactors. The EDA H-mode has been observed recently in the
Anshu Liang, Xiaolan Zou, Wulyu Zhong, Yu Zhou, Guoliang Xiao, Rui Ke, Wenping Guo, Shaobo Gong, Liang Liu, Tengfei Sun, Na Wu, Min Jiang, Yiren Zhu, Shiqin Wang, Guanqun Xue, Xin Yu, Jie Wen, Deliang Yu, Zhongbing Shi, Bo Li, Wei Chen, Xiaoquan Ji   +21 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Density pedestal prediction model for tokamak plasmas

Nuclear Fusion
A model for the pedestal density prediction based on neutral penetration combined with pedestal transport is presented. The model is tested against a pedestal database of JET-ILW Type I ELMy H-modes showing good agreement over a wide range of parameters ...
S. Saarelma, J.W. Connor, P. Bílková, P. Bohm, C. Bowman, A.R. Field, L. Frassinetti, R. Friedström, S. Henderson, K. Imada, A. Kirk, O.J. Kwon, T. Luda, R. Sarwar, R. Scannell, S.F. Smith, the ASDEX Upgrade Team, MAST-U team, STEP team, JET Contributors, the Eurofusion Tokamak Exploitation Team   +20 more
doaj   +1 more source

H-mode dithering phase studies on ST40. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Andrew Y, Bland J, Buxton P, Dnestrovskij A, Gryaznevich M, Kim EJ, Romanelli M, Sertoli M, Thomas P, Varje J.   +9 more
europepmc   +1 more source