Results 181 to 190 of about 141,787 (254)

Sappanwood extract modulates hepatic structure–function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia

Animal Models and Experimental Medicine, EarlyView.
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama, Ratu Safitri, Desak Made Malini, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Madihah Madihah   +5 more
wiley   +1 more source

Reflex Charging for Anion‐Derived Solid Electrolyte Interphase Formation

Angewandte Chemie, EarlyView.
Reflex charging reprograms the electric double layer (EDL) during battery formation by periodically reversing electrode polarity, enabling persistent anion enrichment at the interface. This dynamic interfacial control shifts Li+ solvation toward anion‐coordinated states, promoting the formation of an inorganic‐rich, anion‐derived solid electrolyte ...
Gyeoul Seong, Min‐Gyun Kim, Eunyeong Jung, Yerin Kang, Hong‐I Kim, Kwon‐Hyung Lee, Kohei Shimokawa, Won Bo Lee, Sang‐Young Lee, Seung‐Hyeok Kim   +9 more
wiley   +2 more sources

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Tailoring Photochromism Beyond Human Eye Visibility: On/Off Switchable NIR Absorption in an Aluminosilicate

Angewandte Chemie, EarlyView.
A new photochromic material was developed. Its on/off‐switchable absorption band is situated completely outside the human eye's visibility, in the near‐infrared (NIR) region, a feature never reported before. The photochromism mechanism in this aluminosilicate is elucidated by combining experimental as well as computational results, and the material's ...
Bettiina Muurinen, Hannah Byron, Teppo Kreivilä, Roosa Vastamäki, Sami Vuori, Tomasz Galica, Ian P. Machado, Sari Granroth, Basit Ali, Maarit Karppinen, Ivo Heinmaa, Milica Todorović, Raphael Rullan, Stephan Steinmann, Tangui Le Bahers, Mika Lastusaari   +15 more
wiley   +2 more sources

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Integrating machine learning, deep learning, and image analysis for seed species classification

Applications in Plant Sciences, EarlyView.
Abstract Premise The growing demand for wildflower seeds in ecological restoration requires reliable species identification, yet current market products often contain heterogeneous species. As seed identification is labor‐intensive and requires advanced botanical knowledge, we evaluated multiple segmentation and classification approaches to determine ...
Jonathan Ashworth, Eloise Barrett, Rebonto Haque, Ben Wildey, Anthony Hall, Felix Shaw, Jose J. De Vega   +6 more
wiley   +1 more source

Arthroscopic Bioabsorbable Fixation Achieves Favorable Outcomes for Unstable Knee Osteochondritis Dissecans Lesions Compared With Open Fixation and Metal Implants: A Systematic Review

Arthroscopy, EarlyView.
Purpose To systematically review studies evaluating the outcomes, complication rates, and revision rates among open, arthroscopic, and combined internal fixation techniques for unstable osteochondritis dissecans lesions of the knee, with specific attention to implant type and skeletal maturity.
Harrison S. Fellheimer, Gaston Davis, Christian McCormick, Mark Samuel, William L. Justice, Kevin B. Freedman   +5 more
wiley   +1 more source

Improved Detection of Myositis‐Specific Autoantibodies Using Luciferase Immunoprecipitation Systems Assay: Comparison With Line Blot and Conventional Immunoprecipitation

Arthritis &Rheumatology, EarlyView.
Objective Myositis‐specific autoantibodies guide the diagnosis and classification of idiopathic inflammatory myopathies, but current immunoassays vary in accuracy, particularly for autoantibodies associated with interstitial lung disease. To compare the performance of the luciferase immunoprecipitation systems (LIPS) assay with line blot and ...
Peter D. Burbelo, Iago Pinal‐Fernandez, Maria Casal‐Dominguez, Xin Tian, Shijinqiu Gao, Neha Gupta, Eric W. Robbins, John A. Chiorini, Christopher A. Mecoli, Lisa Christopher‐Stine, Livia Casciola‐Rosen, Andrew L. Mammen, Sonye K. Danoff, Anthony F. Suffredini, Julio A. Huapaya   +14 more
wiley   +1 more source

The impact of family interview on the relationship between medical students and their silent mentor

Anatomical Sciences Education, EarlyView.
Abstract The gross anatomy laboratory course often triggers significant negative emotions in medical students during dissection. While various pedagogical interventions aim to alleviate psychological burden, the fundamental question of how students' perceptions of donors evolve throughout the course remains underexplored.
Po‐Fang Tsai, Mei‐Fang Tseng, Ruei‐Jen Chiou   +2 more
wiley   +1 more source

Ritualized reflection in human dissection: Liminality, ethical negotiation, and professional identity formation among South Korean medical students

Anatomical Sciences Education, EarlyView.
Abstract Human dissection is a foundational component of medical education, yet it places students in profound ethical tension between scientific objectification and respect for human dignity. While prior studies have documented students' emotional responses, the structural transformation of their moral narratives over time, particularly within non ...
Jun‐Ki Lee, Hyoungtae Kim, Hyo Hyun Yoo   +2 more
wiley   +1 more source