Results 141 to 150 of about 1,949,573 (273)

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Phased potato genome assembly and association genetics enable delineation of the H1 resistance locus against potato cyst nematodes. [PDF]

Theor Appl Genet
Cheung YW, Brown LH, Adams TM, Harrower B, Kaur A, McKenzie G, Orr J, Price J, Singh V, Smith M, Bayer M, Hein I.   +11 more
europepmc   +1 more source

H1-receptors [PDF]

Journal of Allergy and Clinical Immunology, 2003
openaire   +1 more source

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

Advanced Science, EarlyView.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu, Liwei Du, Minghao Sun, Kai Zhang, Mingchang Pang, Shangze Jiang, Jiaxun Dong, Xiyue Liu, Bao Jin, Fu Xu, Hang Sun, Jiangang Zhang, Huiyu Yang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao, Shunda Du, Xinting Sang, Yongchang Zheng, Lei Zhang, Xueshuai Wan, Huayu Yang, Yilei Mao   +23 more
wiley   +1 more source

YY1 Interacts with Promoter R-Loops to Regulate Transcription. [PDF]

J Am Chem Soc
He X, Yuan J, Li L, Gao Z, Wang Y.
europepmc   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Structural insights into RNase H catalytic mechanism from room-temperature X-ray and neutron crystallography of apo- and RNA/DNA hybrid-bound enzyme. [PDF]

Curr Res Struct Biol
Gerlits O, Collins A, Kovalevsky A.
europepmc   +1 more source

Outstanding 1200 °C Oxidation Resistance in a Novel Multi‐Principal Element Alloy via Lattice Distortion‐Induced Diffusion Suppression

Advanced Science, EarlyView.
The unique lamellar structure of the eutectic alloy promotes selective oxidation of Al initially, while lattice distortion‐induced diffusion suppression slows oxide growth during steady state. Combining these strategies, a Multi‐Principal Element Alloy with excellent oxidation resistance at 1200℃ was designed.
Xinyu Zhang, Weiyan Lv, Xinguang Wang, Chuanmin Jia, Yizhou Zhou, Keqiang Qiu, Jianqiang Wang   +6 more
wiley   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

Protocol for testing global neuronal workspace and integrated information theories of consciousness in non-human primates and mice. [PDF]

PLoS One
Gibbons M, McBride EG, Holenarasipura Venkatasubbaiah R, Khalili-Ardali M, Kuyat JR, Gale S, LaFehr V, Vogler NW, Kheirkhah Ravandi M, Tsai MJ, Bennett C, Sridhar A, Hardcastle B, Cabasco H, Koch C, Naccache L, Tononi G, Olsen S, Neimark Geffen M, Panagiotaropoulos TI, Saalmann YB.   +20 more
europepmc   +1 more source