Results 131 to 140 of about 176,568 (258)

Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre.
Zhongxing Zhang, Lucie Barateau, Séverine Béziat, Ramin Khatami, Yves Dauvilliers   +4 more
wiley   +1 more source

Ultrastructural organization and reproduction of virions in Vero (E6) cells in influenza A/H1N1 pmd09 virus monoinfection and coinfection with SARS-CoV-2 (Delta and Omicron strains)

Вопросы вирусологии
Introduction. RNA-containing viruses, especially influenza viruses, are of high epidemiological significance. The manifestation of COVID-19 has led to the registration of coinfection cases, the pathogenesis of which is poorly studied.
Ksenia F. Emtsova, Ekaterina V. Spiridonova, Vladimir V. Omigov, Anastasia A. Moiseeva, Elena I. Danilenko, Oleg S. Taranov   +5 more
doaj   +1 more source

H1N1… [PDF]

Prehospital and Disaster Medicine, 2009
openaire   +1 more source

Development of a C5‐Azidoacetamide‐Modified 4‐Amino‐2,3‐Difluorosialic Acid Activity‐Based Probe for Labeling of Influenza A Neuraminidases

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
We report DFSA5Az/DFSA5bio, C5‐azidoacetamide 4‐amino‐2,3‐difluorosialic acid activity‐based probes that trap influenza A viral (IAV) neuraminidases (NA) via a stabilized covalent Tyr‐sialosyl intermediate with hour‐scale reactivation. A bioorthogonal azide enables CuAAC (or one‐step biotin) tagging for activity‐dependent Western‐blot detection at ...
Lemeng Chao, Erianna I. Alvarado‐Melendez, Katherine Marougka, Xuesheng Wu, Cornelis A. M. de Haan, Karin Strijbis, Tom Wennekes   +6 more
wiley   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, Volume 13, Issue 14, 9 March 2026.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, Volume 13, Issue 16, 18 March 2026.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Chemical Constituents of Taxodium mucronatum (Cupressaceae) and Some of Its Endophytic Fungi, and Their In Silico and In Vitro Evaluations as SARS‐CoV‐2 Inhibitors and as Cytotoxic Agents

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Abietanes, pimaranes and cycloartanes were characterized from different plant tissues of Taxodium mucronatum. Curvularins, mycophenolic acids and ergosterol were isolated from some fungal endophytes. The isolated compounds were in silico and in vitro evaluated as antiviral and cytotoxic agents.
Nadia Mendoza, Olivia Pérez‐Valera, Antonio Nieto‐Camacho, María Teresa Ramírez‐Apan, Marcela Guadalupe Téllez‐Martínez, Eleazar M. Escamilla‐Silva, Guillermo Delgado   +6 more
wiley   +1 more source

Influenza virus infection drives upregulation of CD84 across a broad range of immune cells

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Our findings reveal a link between high CD84 expression in humans and recovery from respiratory viral infections. In influenza virus‐infected mice, CD84 is upregulated on a broad range of innate and adaptive immune cell populations, particularly on activated and influenza virus‐specific T‐cell populations and associated with less disease severity ...
Xiaoxiao Jia, Isabelle JH Foo, Hayley A McQuilten, Jeremy Chase Crawford, Aira F Cabug, Deborah Gebregzabher, Janet Chou, Robert C Mettelman, Tanya Novak, Lee‐Ann Van de Velde, Ryan S Thwaites, Adrienne G Randolph, Paul G Thomas, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska, Lukasz Kedzierski, Brendon Y Chua   +17 more
wiley   +1 more source