Results 91 to 100 of about 44,112 (233)

From Lab to Market: Paper‐Based CRISPR Diagnostics and Commercialization Pathways

Advanced Sensor Research, Volume 4, Issue 10, October 2025.
Paper‐based CRISPR diagnostics represents one of the most widely commercialized CRISPR assay technologies, yet challenges remain for broader point‐of‐care use. Abstract The global health landscape is continually challenged by infectious diseases that can swiftly escalate into pandemics, underscoring the need for rapid, accurate, and cost‐effective ...
Selen Dalgan, Qingshan Wei
wiley   +1 more source

MISSEL: a method to identify a large number of small species-specific genomic subsequences and its application to viruses classification [PDF]

, 2016
Continuous improvements in next generation sequencing technologies led to ever-increasing collections of genomic sequences, which have not been easily characterized by biologists, and whose analysis requires huge computational effort.
Babakir Mina, Muhammed, Bertolazzi, Paola, Cella, Eleonora, Ciccozzi, Massimo, Ciotti, Marco, Felici, Giovanni, Fiscon, Giulia, Giovanetti, Marta, Lo Presti, Alessandra, Pierangeli, Alessandra, Weitschek, Emanuel   +10 more
core   +2 more sources

Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers

Brain and Behavior, Volume 15, Issue 10, October 2025.
Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf, Salwa Asif, Abdallah AlSaafeen, Kaviprada Geathaa Dhantapaani, Maryam Muhammad Nadeem, Zohra Kamran Rao, Aliya Shaju Shahul Hameed, Karthik Chintharala, Muhammad Faheem Anwar, Asad Ali Ahmed Cheema   +9 more
wiley   +1 more source

Kinetics of IgA Subtypes and Cytokines in Respiratory Secretions Following Immunization With COVID‐19 Mucosal Vaccine

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT The COVID‐19 pandemic highlights the need for mucosal vaccines inducing respiratory secretory IgA (sIgA), as traditional intramuscular vaccines primarily elicit systemic IgG with limited mucosal protection. This study systematically compared mucosal immune responses induced by two authorized COVID‐19 mucosal vaccines: an orally aerosolized ...
Weixin Chen, Juan Li, Shuang Bai, Ao Zhang, Qun Zheng, Junnan Zhang, Wenwen Lan, Yihan Zhang, Wei Yao, Wei Zhao, Jiang Wu   +10 more
wiley   +1 more source

Assessing Influenza and SARS‐CoV‐2 Coinfection in Brazil: A Comprehensive Study of Patient Outcomes From 2020 to 2023

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Influenza and SARS‐CoV‐2 are major respiratory pathogens that have impacted global health, sharing similar transmission routes and clinical symptoms. The COVID‐19 pandemic brought attention to coinfection with these viruses, which has been associated with worse clinical outcomes, but the full extent of this impact remains underexplored.
L. T. A. Gaklik, B. M. Carneiro
wiley   +1 more source

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells

Respiratory Research, 2005
Background Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum
Poon LLM, Long HT, Chan RWY, Chan YO, Nicholls JM, Tsao SW, Chui WH, Cheung CY, Chan MCW, Guan Y, Peiris JSM   +10 more
doaj   +1 more source

Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13 [PDF]

, 2015
Background Previous influenza surveillance at paediatric intensive care units (PICUs) in Germany indicated increased incidence of PICU admissions for the pandemic influenza subtype A(H1N1)pdm09.
Andrea Streng, Benedikt Weissbrich, Christiane Prifert, Johannes G. Liese, null null   +4 more
core   +1 more source

Efficacy of Oseltamivir Against Seasonal Influenza H1N1 and the Efficacy of a Novel Combination Treatment In Vitro and In Vivo in Mouse Studies

Influenza and Other Respiratory Viruses, Volume 19, Issue 10, October 2025.
ABSTRACT Background Influenza surveillance and drug resistance testing have always been central to clinical efforts. Therefore, researching the virus characteristics and antiviral drugs is essential. Method The HA and NA activities were assessed in influenza strains, and mutations were identified through gene sequencing.
Danlei Liu, Ka‐Yi Leung, Ruiqi Zhang, Hoi‐Yan Lam, Yujing Fan, Xiaochun Xie, Wan‐Mui Chan, Kelvin Kai‐Wang To, Kwok‐Hung Chan, Ivan Fan‐Ngai Hung   +9 more
wiley   +1 more source

Verification of the Combimatrix influenza detection assay for the detection of influenza A subtype during the 2007–2008 influenza season in Toronto, Canada

Virology Journal, 2009
The increase in adamantine resistance in influenza A (H3N2) and the emergence of oseltamivir resistance in influenza A (H1N1) has necessitated the use of rapid methodologies to detect influenza subtype.
Blair Joanne, Eshaghi AliReza, Yeung Rani, Lombos Ernesto, Bolotin Shelly, Drews Steven J   +5 more
doaj   +1 more source

Present and Future of Central Disorders of Hypersomnolence

Journal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT Central disorders of hypersomnolence (CDH) are rare neurological conditions lumped by excessive daytime sleepiness (EDS) as primary complaint mostly arising at young age, including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine‐Levin syndrome (KLS). Advances in clinical and translational research have
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source