Results 121 to 130 of about 41,916 (253)

Early Prediction of Antigenic Transitions for Influenza A H3N2

PLOS Computational Biology, 2019
AbstractInfluenza A/H3N2 is a rapidly evolving virus which experiences major antigenic transitions every two to eight years. Anticipating the timing and outcome of transitions is critical to developing effective seasonal influenza vaccines. Using simulations from a published phylodynamic model of influenza transmission, we identified indicators of ...
Lauren A. Castro, Trevor Bedford, Lauren Ancel Meyers   +2 more
openaire   +4 more sources

Dynamic adaptation mutations and pathogenic characterization of a mouse-adapted seasonal human H3N2 influenza virus

Virology Journal
Background H3N2 influenza A viruses [A(H3N2)] circulate as seasonal influenza in humans worldwide, resulting in a huge disease burden. Adaptation study of A(H3N2) in mice could provide a basis for preclinical evaluation of antivirals and vaccines ...
Cheng Zhang, Yan Li, Ning Zhang, Ju Sun, Deyu Tian, Xuefeng Duan, Jing Yang, Yuhai Bi   +7 more
doaj   +1 more source

Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs

Journal of Virology
As companion animals, dogs are susceptible to various subtypes of influenza A virus (IAV), with the H3N2 and H3N8 subtypes of canine influenza virus (CIV) stably circulating among canines.
Xiangyu Xiao, Xinrui Wang, Fengpei Xu, Yanting Liang, Yi Luo, Shoujun Li, Pei Zhou   +6 more
doaj   +1 more source

Impact of the baloxavir-resistant polymerase acid (PA) I38T substitution on the fitness of contemporary influenza A(H1N1)pdm09 and A(H3N2) strains.

Journal of Infectious Diseases, 2019
BACKGROUND Baloxavir is a cap-dependent inhibitor of the polymerase acid (PA) protein of influenza viruses. While appearing virologically superior to oseltamivir, baloxavir exhibits a low barrier of resistance.
Liva Checkmahomed, Zeineb M'hamdi, J. Carbonneau, Marie-Christine Venable, M. Baz, Yacine Abed, G. Boivin   +6 more
semanticscholar   +1 more source

Efficacy and Safety in Dogs Following Administration of an Alphavirus RNA Particle Canine Influenza H3N2 Vaccine

Vaccines
Canine influenza virus (CIV) H3N2 causes a highly contagious respiratory disease in dogs and has been the source of outbreaks across North America since 2015.
Haley M. Classe, Jennifer C. Dant, Mark Mogler, Kenneth A. Stachura, Rhonda L. LaFleur, Zach Xu, Ian Tarpey   +6 more
doaj   +1 more source

Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase

Scientific Reports, 2017
Lonicera japonica Thunb, rich in chlorogenic acid (CHA), is used for viral upper respiratory tract infection treatment caused by influenza virus, parainfluenza virus, and respiratory syncytial virus, ect in China.
Yue Ding, Ze-yu Cao, Liang Cao, G. Ding, Zhenzhong Wang, W. Xiao   +5 more
semanticscholar   +1 more source

A Dose Finding Study of a Wild-Type Influenza A/H3N2 virus in a Healthy Volunteer Human Challenge Model.

Clinical Infectious Diseases, 2019
BACKGROUND The development of vaccines and therapeutics have relied on healthy volunteer influenza challenge studies. A validated human infection model with wild-type A(H1N1)pdm09 was reported previously. OBJECTIVE To characterize a wild-type Influenza
A. Han, Lindsay M Czajkowski, A. Donaldson, Holly Ann Baus, Susan M Reed, Rani Athota, T. Bristol, Luz Angela Rosas, Adriana Cervantes-Medina, J. Taubenberger, Matthew J. Memoli   +10 more
semanticscholar   +1 more source

Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15–64-year-olds in Europe: exploration by birth cohort

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019
Introduction Influenza A(H3N2) clades 3C.2a and 3C.3a co-circulated in Europe in 2018/19. Immunological imprinting by first childhood influenza infection may induce future birth cohort differences in vaccine effectiveness (VE). Aim The I-MOVE multicentre
E. Kissling, F. Pozo, S. Buda, A. Vilcu, A. Gherasim, M. Brytting, L. Domegan, Verónica Gómez, A. Meijer, M. Lazăr, V. V. Vučina, R. Dürrwald, S. van der Werf, A. Larrauri, T. Enkirch, J. O’Donnell, R. Guiomar, M. Hooiveld, G. Petrović, Elena Stoian, P. Penttinen, M. Valenciano   +21 more
semanticscholar   +1 more source

Polymerase activity of hybrid ribonucleoprotein complexes generated from reassortment between 2009 pandemic H1N1 and seasonal H3N2 influenza A viruses

Virology Journal, 2011
Background A novel influenza virus (2009 pdmH1N1) was identified in early 2009 and progressed to a pandemic in mid-2009. This study compared the polymerase activity of recombinant viral ribonucleoprotein (vRNP) complexes derived from 2009 pdmH1N1 and the
Lam Wai Y, Ngai Karry LK, Chan Paul KS
doaj   +1 more source

Newly Emerging Mutations in the Matrix Genes of the Human Influenza A(H1N1)pdm09 and A(H3N2) Viruses Reduce the Detection Sensitivity of Real-Time Reverse Transcription-PCR [PDF]

, 2013
Ji‐Rong Yang, Chuan‐Yi Kuo, Hsiang‐Yi Huang, Fu-Ting Wu, Yi-Lung Huang, Chieh-Yu Cheng, Yu-Ting Su, Feng‐Yee Chang, Ho-Sheng Wu, Ming‐Tsan Liu   +9 more
openalex   +1 more source