Results 101 to 110 of about 51,349 (223)

Attenuation of Influenza a Virus into Live Vaccines Through C‐End Degrons

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Naturally occurring C‐end degrons are exploited to design proteolysis‐targeting live attenuated influenza vaccines. C‐end degron tagging of viral M1 protein promotes proteasome‐dependent degradation, resulting in robust attenuation in host cells while permitting scalable production in engineered cells.
Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen‐xia Tian, Longlong Si   +14 more
wiley   +1 more source

Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]

, 2013
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
A Ali, A Harris, A Moeller, A Smirnov Yu, BE Eddy, BJ Chen, C Loney, C Scholtissek, CJ Elleman, CM Chu, Colin Loney, D McGeoch, David Bhella, David Jackson, DN Mastronarde, E Fournier, Frazer J. Rixon, GL Ada, I Archetti, JR Gog, JR Kremer, JS Rossman, JS Rossman, KB Renegar, L Hoyle, L Liljeroos, LJ Calder, LM Burleigh, M Adrian, P Palese, PC Roberts, PC Roberts, Peter Palese, R Arranz, RA Lamb, RA Lamb, RW Compans, RW Ruigrok, Swetha Vijayakrishnan, T Noda, T Noda, TA Bharat, V Doceul, Worawit Suphamungmee, Y Fujii, Y Geng   +45 more
core   +3 more sources

Acute Respiratory Distress Syndrome in Adult Patient With RSV Infection: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT We described the case of a 54‐year‐old woman with no history of immunodeficiencies admitted to the ICU of our university hospital due to acute respiratory failure and ARDS secondary to severe community‐acquired pneumonia (sCAP) caused by RSV infection.
Gioacchina Martina Campione, Mario Alessio Guarano, Mariachiara Ippolito, Giulia Catalisano, Giulia Lo Scrudato, Ilenia Giacchino, Erika Mannino, Teresa Maria Assunta Fasciana, Giovanni Giammanco, Cesira Palmeri di Villalba, Santi Maurizio Raineri, Andrea Cortegiani, Antonino Giarratano   +12 more
wiley   +1 more source

Genetic content of Influenza H3N2 vaccine seeds

PLoS Currents, 2010
Influenza vaccine seeds produced in chicken eggs are selected through HA and NA surface glycoproteins antigenicity, as well as through high replicative ability. Here we characterize the genetic content of recently used thirteen H3N2 influenza vaccine seeds.
Bergeron, Corinne, Valette, Martine, Lina, Bruno, Ottmann, Michele   +3 more
openaire   +4 more sources

Africa's Struggle to Meet Global Pandemic Influenza Immunization Targets: Lessons for Public Health Policy and Preparedness—A Focus on Ghana

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Influenza remains a significant yet under‐prioritized public health challenge in Africa, where unique hurdles such as limited surveillance, variable seasonal patterns, and under‐resourced health systems constrain effective prevention and control. This commentary provides a detailed analysis of the influenza landscape, with a focused
Yula Salifu, Joseph Lasong, Ireneous Nangbeviel Dasoberi   +2 more
wiley   +1 more source

Emerging viral respiratory tract infections—environmental risk factors and transmission [PDF]

, 2014
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Charrel, Remi N., Gautret, Philippe, Gray, Gregory C., Memish, Ziad A., Odezulu, Nnanyelugo G., Zumla, Alimuddin   +6 more
core   +1 more source

Respiratory Viral Co‐Infections in SARS‐CoV‐2 Positive Patients in Burkina Faso: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background The burden of viral co‐infections among COVID‐19 patients is underexplored in low‐resource settings such as Burkina Faso. This study aimed to determine the prevalence and associated factors of respiratory viral co‐infections among laboratory‐confirmed COVID‐19 patients. Methods A cross‐sectional study was conducted from January 1 to
Benjamin W. O. Kaboré, Nina Gouba, Abdoul Kader Ilboudo, Assana Cissé, Moussa Lingani, Cathérine Sawadogo, Ezéchiel Wendinda Ouédraogo, Jean Bienvenue Ouoba, Madi Savadogo, Zékiba Tarnagda   +9 more
wiley   +1 more source

Dynamic adaptation mutations and pathogenic characterization of a mouse-adapted seasonal human H3N2 influenza virus

Virology Journal
Background H3N2 influenza A viruses [A(H3N2)] circulate as seasonal influenza in humans worldwide, resulting in a huge disease burden. Adaptation study of A(H3N2) in mice could provide a basis for preclinical evaluation of antivirals and vaccines ...
Cheng Zhang, Yan Li, Ning Zhang, Ju Sun, Deyu Tian, Xuefeng Duan, Jing Yang, Yuhai Bi   +7 more
doaj   +1 more source

Lower cellular immune responses to influenza A (H3N2) in the elderly

Journal of Medical Virology, 2009
AbstractInfluenza epidemic is an important cause of severe illness in the elderly. Age‐dependent morbidity of influenza in the elderly is associated with weakened immunity. The baseline age‐related memory T cell activity in Chinese persons who are exposed to influenza virus through natural infection, are associated with the protective response to the ...
Jia, N, Li, C, Liu, Y, Richardus, J, Feng, D, Yang, H, Dang, R, Ma, Y, Xu, X, Cao, W   +9 more
openaire   +2 more sources

Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs

Journal of Virology
As companion animals, dogs are susceptible to various subtypes of influenza A virus (IAV), with the H3N2 and H3N8 subtypes of canine influenza virus (CIV) stably circulating among canines.
Xiangyu Xiao, Xinrui Wang, Fengpei Xu, Yanting Liang, Yi Luo, Shoujun Li, Pei Zhou   +6 more
doaj   +1 more source