Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR [PDF]
Scientific Reports, 2019 The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who ...
Lorena Vigón +14 more
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Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design [PDF]
Nature CommunicationsHepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. Development of an E1E2-based HCV vaccine has been hindered by the difficulty of producing a soluble E1E2 (sE1E2) antigen that ...
Linling He +17 more
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“Influence of plasmids, selection markers and auxotrophic mutations on Haloferax volcanii cell shape plasticity” [PDF]
Frontiers in Microbiology, 2023 Haloferax volcanii and other Haloarchaea can be pleomorphic, adopting different shapes, which vary with growth stages. Several studies have shown that H.
Megha Patro +4 more
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Selection and characterization of a broadly neutralizing class of HCV anti-E2 VH1-69 antibodies. [PDF]
PLoS PathogensIdentification and characterization of antibody epitope targets on the hepatitis C virus (HCV) envelope proteins remain crucial for developing an effective vaccine.
Andreas Soerensen +11 more
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Targeted Removal of HCV E2 N2 N-Glycan Is Associated with Improved Immune Responses in Mice [PDF]
BiomoleculesHepatitis C virus (HCV) still lacks a licensed vaccine. The envelope glycoprotein E2 is a key neutralizing target, but its dense N-glycan shield can hinder epitope exposure.
Yuan-Qin Min +4 more
doaj +2 more sources
UNDERSTANDING INTRA-HOUSEHOLD EXPENDITURE DISTRIBUTION IN INDONESIA
Economic Journal of Emerging Markets, 2014 Decentralisation provides regional government with greater authority to deliver various public services. It is expected that decentralisation will improve people welfare due to proximity. This study is aimed to investigate whether there is improvement in
Heru Wibowo
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Spatial interactions in local public debt. Evidence from Poland
Economics and Business Review, 2023 The aim of the paper is to investigate spatial interactions among the debt of 2,442 municipalities in Poland over the period 2005–2020. Using the dynamic spatial Durbin model with two-way fixed effects, it provides empirical evidence of positive spatial ...
Banaszewska Monika
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Acta Universitatis Sapientiae: Economics and Business, 2023 This study tries to empirically estimate the effects of the composition of intergovernmental transfers on tax collection across the Indian states by using panel regression model.
Kumar Sumit, Kaur Baljit
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Genotype 1a HCV (H77S) Infection System
PLoS ONE, 2009 HCV is a small RNA virus belonging to the genus Hepacivirus within the virus family Flaviviridae. Infection with HCV often leads to chronic liver diseases including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Current therapy, based on the use of interferon-alpha (IFN-alpha) in combination with ribavirin, results in limited success,
Minkyung, Yi, Stanley M, Lemon
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Efficient Infectious Cell Culture Systems of the Hepatitis C Virus (HCV) Prototype Strains HCV-1 and H77 [PDF]
Journal of Virology, 2015 ABSTRACT The first discovered and sequenced hepatitis C virus (HCV) genome and the first in vivo infectious HCV clones originated from the HCV prototype strains HCV-1 and H77, respectively, both widely used in research of this important human pathogen.
Li, Yi-Ping +3 more
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