Results 41 to 50 of about 3,728 (189)

Two different NS5A dimer-interface mutations impaired both gt1a H77 and gt2a JFH1 NS5A self-interactions.

, 2018
(A) An NS5A self-interaction was determined by performing a checkmate mammalian two-hybrid assay in Huh-7 cells. Interaction between GAL4/BD (GAL4 DNA binding domain)-fused protein and VP16/AD (VP16 activation domain)-fused protein resulted in increased ...
Alyssa K. Nichols (5545664), MinKyung Yi (362029), Saravanabalaji Shanmugam (5545667), Dhanaranjani Saravanabalaji (5545670), Christoph Welsch (22852)   +4 more
core   +1 more source

Variable regions exhibit high flexibility.

, 2020
Shannon entropy provides a measure of diversity with high values indicating low conservation. A. H77 E2 model color-coded for Shannon entropy; variable regions have high values. B.
Machaela Palor (8506497), Richard J. Bingham (2044882), Lenka Stejskal (8506488), Joe Grove (6476039), William D. Lees (8506491), Adrian J. Shepherd (7617149), David S. Moss (8506494)   +6 more
core   +1 more source

Elamipretide Improves Mitochondrial Function in Mitochondrial Trifunctional Protein‐Deficient Mice and Human Fibroblasts

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Mitochondrial trifunctional protein (TFP) deficiency is an inherited disorder of long‐chain fatty acid β‐oxidation (FAO). TFP is a heteromeric enzyme composed of two α and two β‐subunits. Despite early detection and dietary treatment, TFP deficiency patients often develop hypoglycemia, rhabdomyolysis, cardiomyopathy, and peripheral neuropathy.
Eduardo Vieira Neto, Meicheng Wang, Austin J. Szuminsky, Lethicia Ferraro, Shakuntala Basu, Xuejun Zhao, Anuradha Karunanidhi, Yudong Wang, Jerry Vockley   +8 more
wiley   +1 more source

Amino acid alterations identified in H77 HCV E1/E2 envelope glycoproteins after initial viral infection in untreated (#1) and treated (#2) chimpanzees.

, 2013
Amino acid alterations identified in H77 HCV E1/E2 envelope glycoproteins after initial viral infection in untreated (#1) and treated (#2) chimpanzees.
Robert E. Lanford (206807), Gyongyi Szabo (128056), Robert H. Purcell (284615), Steve W. Ludmerer (309483), Donna M. Ambrosino (309486), Michael Knauber (309481), Gregory J. Babcock (309493), Barbra M. Blair (309477), Robert W. Finberg (247603), Yang Wang (5921), Deborah C. Molrine (309489), Teresa J. Broering (309475), Peter S. Cheslock (309480), Elisabeth N. Boucher (309479), Kirk J. Rowley (309478), David B. Olsen (309482), Trevor J. Morin (309474), Brett A. Leav (309476)   +17 more
core   +1 more source

Sick of Robots—Heterogeneous Effects of Industrial Robots on Sickness Absence

Health Economics, Volume 34, Issue 10, Page 1882-1906, October 2025.
ABSTRACT This paper studies how the introduction of industrial robots affects sickness absence among workers in the manufacturing sector in Norway. We use data on the imports of industrial robots at the firm level, combined with employee‐firm linked register data, to investigate the impact of robotization on the duration of sick leave (SL).
Janis Umblijs, Kjersti Misje Østbakken
wiley   +1 more source

Culturing H77/JFH1 and J6/JFH1 with AR5A resulted in low or negligible escape.

, 2017
(A-B) Huh7.5 cells were infected with (A) H77/JFH1 and treated with 5 μg/ml (treatment I) or 200 μg/ml (treatment II) of AR5A or with (B) J6/JFH1 and treated with 20 μg/ml (treatment I) or 200 μg/ml (treatment II) of AR5A.
Mansun Law (320712), Jens Bukh (162343), Rodrigo Velázquez-Moctezuma (3776023), Jannick Prentoe (162323)   +3 more
core   +1 more source

Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

, 2014
Hypervariable region 1 (HVR1) of envelope protein 2 (E2) of hepatitis C virus (HCV) serves important yet undefined roles in the viral life cycle. We previously showed that the viability of HVR1-deleted JFH1-based recombinants with Core-NS2 of H77 (H77 ...
Prentoe, Jannick, Serre, Stéphanie B N, Bukh, Jens, Ramirez, Santseharay, Nicosia, Alfredo   +4 more
core   +2 more sources

Harmonizing the complexities of financial development and fiscal decentralization in highly populated nations for monitoring environmental quality

Heliyon
The increasing challenges posed by global warming underscore the need to examine the contributing factors comprehensively. This study explores the complex interaction that enhances the financial autonomy of local governments (fiscal decentralization ...
Yi Ding, Fayaz Hussain Tunio, Agha Amad Nabi   +2 more
doaj   +1 more source

Hepatitis C genotype 1a replicon improved through introduction of fitness mutations

BioTechniques, 2012
The use of subgenomic replicon systems has long been a valuable screening tool for the discovery of small molecule antivirals against Hepatitis C virus.
Christian Voitenleitner, Jill Bechtel, Ann Arfsten, Robert Hamatake   +3 more
doaj   +1 more source

Complex population genetic structure of the bark beetle predator Thanasimus formicarius (L.) (Coleoptera: Cleridae) across its European range

Agricultural and Forest Entomology, Volume 27, Issue 3, Page 437-451, August 2025.
Abstract Thanasimus formicarius (L.) (Coleoptera: Cleridae) is an important bark beetle predator and can reduce bark beetle population densities of some of the most severe forest pests in Europe. We analysed the population genetics and phylogeography of T.
Eva Papek, Amina Derlić, Markus Melin, Alain Roques, Dragos Cocos, Martin L. Schroeder, Milan Pernek, Dimitrios N. Avtzis, Paulius Zolubas, David T. Williams, Juan A. Pajares, Oğuzhan Sarikaya, Roman Pavlin, Sevdalin Belilov, Martin M. Gossner, M. Lukas Seehausen, Anna Wierzbicka, Lara Kundtner, Christian Stauffer, Martin Schebeck   +19 more
wiley   +1 more source