Results 251 to 260 of about 1,094,944 (319)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

CFP1-mediated H3K4me3 broad domains control early B cell lineage fate determination. [PDF]

Nucleic Acids Res
Bai W, Yang Y, Zhao Y, Gong S, Lu Y, Xue Z, Wang L, Meng FL, Chen C, Dong J.   +9 more
europepmc   +1 more source

The Dust-heating Sphere of Influence of H  ii Regions in M33

Shangqi Liu, Karin Sandström, Adam Leroy, Rebecca McClain   +3 more
openalex   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila. [PDF]

Nat Genet
Maziak N, Zhang Y, Groll F, Brown HE, Madich A, Kaur Y, Harrison MM, Zhou J, Vaquerizas JM.   +8 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Quantum Biochemistry Insights into Ligand Recognition at the a_1A-Adrenoceptor. [PDF]

ACS Omega
Talinne da Costa Gomes L, Bezerra KS, Gavioli EC, Nobre Oliveira JI, Galvão DS, Fulco UL, Dantas da Silva Junior E.   +6 more
europepmc   +1 more source

AN H-II REGION NEAR NML CYGNUS

Astronomy & Astrophysics, 1982
Habing, H.J., Goss, W.M., Winnberg, A.
openaire   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source