Results 251 to 260 of about 1,861,445 (361)

Fourier transform infrared spectroscopy detects distinct TAR DNA-binding protein 43 signatures in frontotemporal lobar degeneration. [PDF]

Front Neurosci
Gatto RG, Gakh O, Wilkins JM, Carlos AF, Youssef H, Guo Y, Whitwell JL, Josephs KA, Lucchinetti CF.   +8 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Therapeutic Perspectives of SIRT6 Regulation: Computational Analysis of Activation and Inhibition by Bioactive Molecules. [PDF]

J Mol Recognit
de Carvalho Matias ÉG, Bezerra KS, Junior WSC, Oliveira JIN, Galvão DS, Fulco UL.   +5 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Cerebellar subregional structural changes across the Alzheimer's disease continuum: a longitudinal analysis of cognitive and behavioural correlates. [PDF]

Brain Commun
Um YH, Wang SM, Kang DW, Kim S, Kim S, Kim D, Choe YS, Kim REY, Lim HK.   +8 more
europepmc   +1 more source

A search for hypercompact H iiregions in the Galactic Plane

, 2018
A. Y. Yang, M. A. Thompson, W. W. Tian, S. Bihr, H. Beuther, L. Hindson   +5 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

M-Ras distinct activation scenarios: A mechanistic outlook and targeting. [PDF]

Comput Struct Biotechnol J
Xu L, Liu Y, Jang H, Nussinov R.
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Exploring the chemical and biological landscape of a Nickel (II) schiff base complex via azomethine linkage. [PDF]

Sci Rep
Venkatesh R, Murugan T, Kubaib A, Umamaheswari L, Imran PM, AbdelGawwad MR, Alayadi H, Alfrisany NM.   +7 more
europepmc   +1 more source