Results 91 to 100 of about 387,641 (271)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Regional policy from a regional geographical point of view: A comparison of Dutch provinces Friesland and Zeeland

Fennia: International Journal of Geography, 1993
The methodological debates about comparative analysis in the social sciences are highly relevant for regional geography. Once the theoretical foundations of the unique are accepted, it is possible to design regional geographic models and to compare ...
G. A. Hoekveld, G Hoekveld-Meijer
doaj  

A social marketing perspective of young people’s sexual health

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityBACGROUND:Unintended pregnancy and sexually transmitted infections among young people are priority public health issues in the UK.
Wakhisi, Anthony Simiyu
core  

The Influence of Social Location on the Experience of Early Dementia [PDF]

, 2014
This thesis investigates the intersections of social class and gender with the early dementia experience. 20 older people with a likely dementia diagnosis were recruited from memory clinic referrals. Unstructured interviews were conducted in the person’s
Peet, Julie
core  

Chimpanzees Extract Social Information from Agonistic Screams [PDF]

, 2010
Chimpanzee (Pan troglodytes) agonistic screams are graded vocal signals that are produced in a context-specific manner. Screams given by aggressors and victims can be discriminated based on their acoustic structure but the mechanisms of listener ...
Josep Call, Zuberbühler Klaus, Zuberbühler, Klaus, Call, Josep, Kaller Tanja, Kaller, Tania, Slocombe Katie E., Kaller, Tanja, Klaus Zuberbühler, Slocombe, K., Slocombe, Katie E, Evolutionary Anthropology, Leipzig, Germany, Katie E. Slocombe, Kaller, T., Zuberbühler, K., Slocombe, Katie E., Katie E Slocombe, Call, J. ; https://orcid.org/, Zuberbuehler, Klaus, Tanja Kaller, Call Josep   +20 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Serious mental health conditions and exposure to adulthood trauma in low- and middle-income countries: a scoping review

Cambridge Prisms: Global Mental Health
Background There is a strong link between trauma exposure and serious mental health conditions (SMHCs), such as schizophrenia and bipolar disorder. The majority of research in the field has focused on childhood trauma as a risk factor for developing an ...
Anne Stevenson, Engida Girma, Benon Kabale Kitafuna, Boniface Harerimana, Karestan C. Koenen, Soraya Seedat   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Network Analysis of Insomnia in Chinese Mental Health Professionals During the COVID-19 Pandemic: A Cross-Sectional Study

Nature and Science of Sleep, 2021
Wei Bai,1– 3,* Yanjie Zhao,1– 3,* Fengrong An,4,* Qinge Zhang,4,* Sha Sha,4,* Teris Cheung,5 Calvin Pak-Wing Cheng,6 Chee H Ng,7 Yu-Tao Xiang1– 3 1Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute
Bai W, Zhao Y, An F, Zhang Q, Sha S, Cheung T, Cheng CPW, Ng CH, Xiang YT   +8 more
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