Results 111 to 120 of about 2,070,514 (345)

Nurr1 Orchestrates Claustrum Development and Functionality

open access: yesAdvanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan   +12 more
wiley   +1 more source

Three Good Steward Habits [PDF]

open access: yes, 2011
[Excerpt] I learned these habits from a former colleague, Jessica Govea Thourborne, who developed them when she was one of the founding members of the United Farm Workers Union with Caesar Chavez.
Margolies, Ken A
core   +1 more source

Social representations of feeding people with type-2 diabetes mellitus [PDF]

open access: yes, 2016
The aim of this study was to analyze the social representations of the diets 34 patients of the Brazilian public primary care service diagnosed with type- 2 diabetes mellitus, according to how they represent their identity.
Amorim, Maria Marta Amancio   +2 more
core   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Meat Demand under Rational Habit Persistence [PDF]

open access: yes
The objective of this paper is to explore the theoretical implications of a meat demand model with rational habits. To introduce consumption dynamics, habit persistence is used to motivate intertemporally related preferences.
Wohlgenant, Michael K., Zhen, Chen
core   +1 more source

Habiter, habitants et habitats

open access: yesCalenda, 2021
Le domicile constitue un enjeu sociétal majeur, parce qu’il est le creuset de nombreux aspects de la vie personnelle et sociale, parce qu’il apparaît de plus en plus comme un lieu pluri-finalisé, lieu de projets et objet de nombreux réinvestissements.
openaire   +1 more source

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

open access: yesAdvanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller   +3 more
wiley   +1 more source

Habit Formation, Parents' Education Spending, and Growth [PDF]

open access: yes
This paper investigates the impact of habits on economic growth in an overlapping generations (OLG) economy with physical and human capital in which altruistic parents finance the education of their children.
Takeshi Nakata
core  

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

open access: yesAdvanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen   +8 more
wiley   +1 more source

Triple-System Theory of Individual Decision-Making Based on the Concept of Flux

open access: yesAlterEconomics
Although the topic of human decision-making is as vast as it is old, there is still no widely recognized computational model in both economic theory and interdisciplinary studies.
Victor A. ISTRATOV
doaj   +1 more source

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