Results 91 to 100 of about 1,237,626 (349)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Habitual intake of flavonoid subclasses and risk of colorectal cancer in two large prospective cohorts [PDF]

, 2016
Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one sub-class, flavonols, was significantly associated with reduced risk of
Aedín Cassidy, Andrew T Chan, Arts, Bobe, Cassidy, Cassidy, Charles S Fuchs, Colditz, Cutler, DerSimonian, Devore, Edward L Giovannucci, Eric B Rimm, Feskanich, Fini, Gao, Giovannucci, Hirvonen, Hu, Jennifer H Lin, Kana Wu, Kandaswami, Katharina Nimptsch, Knekt, Knekt, Kyle, Lambert, Lee, Lin, Mahmoud, McCullough, Mingyang Song, Moon, Mursu, Park, Platz, Rich-Edwards, Rimm, Rossi, Rossi, Sacks, Salvini, Shuji Ogino, Simons, Stampfer, Theodoratou, Tobias Pischon, Voorrips, Walter C Willett, Wei, Willett, Willett, Willett, Williamson, Williamson, Woo, Xuehong Zhang, Yamauchi, Yang, Yu, Yuan, Zamora-Ros, Éilis J O’Reilly   +62 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LEXAMBIENTE Rivista Trimestrale di Diritto Penale dell’Ambiente Fasc. n. 4/2019 38 Il reato di trasporto di rifiuti (art. 256, 1° comma, d.lgs. 152/06): istantaneità vs permanenza The crime of transportation of waste (art. 256, 1st paragraph, d.lgs. 152/06): instantaneousness vs permanence

Lexambiente, 2019
The paper criticizes the Court of Cassation which qualifies the case of the illegal transport of waste (art. 256, 1st paragraph, Legislative Decree 152/06) as an instantaneous or, at the most, possibly habitual offense and instead affirms its nature ...
Vincenzo Paone
doaj  

Sons, Brothers and Relatives in the Entourages of the Roman Provincial Commanders during the Republic: A Characteristic Behaviour of the Roman Ruling Class [PDF]

, 2017
Durante la época de la República era una costumbre bien conocida que el cónsul o pretor destinado a una provincia se dotara de una serie de colaboradores y acompañantes que constituían la cohors o comitiva del imperator.
Díaz Fernández, Alejandro
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

METABOLOMICS IN THE IDENTIFICATION OF BIOMARKERS OF DIETARY INTAKE

Computational and Structural Biotechnology Journal, 2013
Traditional methods for assessing dietary exposure can be unreliable, with under reporting one of the main problems. In an attempt to overcome such problems there is increasing interest in identifying biomarkers of dietary intake to provide a more ...
Aoife O'Gorman, Helena Gibbons, Lorraine Brennan   +2 more
doaj   +3 more sources

Manejo de la dislipemia aterogénica en Atención Primaria: descripción de la práctica clínica habitual (Estudio Avanza) = Management of Atherogenic Dyslipidemia in Primary Care: description of Routine Clinical Practice (AVANZA Study)

, 2021
Jessica Capón Álvarez
openalex   +1 more source

Habitually Barefoot Children Inadvertently Resigned To Wear Ill-Fitting School Shoes: A Cross-Sectional Study [PDF]

, 2021
Marise Carina Breet, Ranel Venter
openalex   +1 more source