Results 91 to 100 of about 1,166,203 (410)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Q fever outbreak in the terraced vineyards of Lavaux, Switzerland

New Microbes and New Infections, EarlyView., 2014
Abstract Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux ...
C. Bellini, I. Magouras, C. Chapuis‐Taillard, O. Clerc, E. Masserey, G. Peduto, O. Péter, S. Schaerrer, G. Schuepbach, G. Greub   +9 more
wiley   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Fonte habitual de cuidado em saúde e o uso de serviços de saúde sexual e reprodutiva entre mulheres trabalhadoras do sexo no Brasil

Cadernos de Saúde Pública, 2021
Ter uma fonte habitual de cuidado pode melhorar o acesso a serviços de saúde e ações de prevenção. Assim, o objetivo foi estimar a proporção e fatores associados à fonte habitual de cuidado entre mulheres trabalhadoras do sexo.
Talita Castro Garcia Matteoni, Laio Magno, Carla Gianna Luppi, Alexandre Grangeiro, Celia Landmann Szwarcwald, Inês Dourado   +5 more
doaj   +2 more sources

'A habitual disposition to the good': on reason, virtue and realism [PDF]

, 2015
Amidst the crisis of instrumental reason, a number of contemporary political philosophers including Jürgen Habermas have sought to rescue the project of a reasonable humanism from the twin threats of religious fundamentalism and secular naturalism.
Agamben G., Agamben G., Aristotle, Bauman Z., Bellah R., Benedict, Berlin I., Bruni L., Debord G., Edelman M., Foucault M., Geuss R., Goetz S., Gray J., Gray J., Gray J., Habermas J., Habermas J., Habermas J., Habermas J., Habermas J., Habermas J., Habermas J., Hirst P. Q., Jaspers K., Juergensmeyer M., Juergensmeyer M., Macintyre A., Manent P., Michéa J.-C., Milbank J., Moreland J. P., Muralt A. D., Nancy J.-L., Nicholls D., Northcott M., Pabst A., Planinc Z., Plato, Polanyi K., Popper K. R., Rawls J., Rawls J., Rawls J., Rawls J., Rawls J., Sandel M. J., Sandel M. J., Scott J. C., Taylor C., Taylor C., Taylor C., Taylor C., Thompson E. P., Williams B., Williams B., Wolin S. S.   +56 more
core   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

Associations between changes in habitual sleep duration and lower self-rated health among COVID-19 survivors: findings from a survey across 16 countries/regions

BMC Public Health, 2023
Background Self-rated health (SRH) is widely recognized as a clinically significant predictor of subsequent mortality risk. Although COVID-19 may impair SRH, this relationship has not been extensively examined.
Kentaro Matsui, Frances Chung, Adrijana Koscec Bjelajac, Ilona Merikanto, Maria Korman, Sérgio Mota-Rolim, Ana Suely Cunha, Bjørn Bjorvatn, Pei Xue, Christian Benedict, Charles M. Morin, Colin A. Espie, Anne-Marie Landtblom, Thomas Penzel, Luigi De Gennaro, Brigitte Holzinger, Harald Hrubos-Strøm, Damien Leger, Courtney J. Bolstad, Michael R. Nadorff, Giuseppe Plazzi, Catia Reis, Ngan Yin Chan, Yun Kwok Wing, Juliana Yordanova, Yves Dauvilliers, Markku Partinen, Yuichi Inoue   +27 more
doaj   +1 more source

Gait speed characteristics and Its spatiotemporal determinants in nursing home residents: A cross-sectional study [PDF]

, 2019
Fien, S ORCiD: 0000-0003-0181-5458BACKGROUND AND PURPOSE: Low and slowing gait speeds among nursing home residents are linked to a higher risk of disability, cognitive impairment, falls, and mortality.
Climstein, Mike, Fien, Samantha, Henwood, Timothy, Keogh, Justin William Leslie, Rathbone, Evelyne   +4 more
core   +2 more sources

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source