Results 51 to 60 of about 1,259,407 (401)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

General habit propensity relates to the sensation seeking subdomain of impulsivity but not obesity

Frontiers in Behavioral Neuroscience, 2016
According to dual-system theory, instrumental learning and performance depend on the balance between goal-directed and habitual action control. Overreliance on habits has been argued to characterize clinical conditions such as drug addiction or obsessive-
Anja Dietrich, Sanne De Wit, Annette Horstmann, Annette Horstmann, Annette Horstmann   +4 more
doaj   +1 more source

Gait speed characteristics and Its spatiotemporal determinants in nursing home residents: A cross-sectional study [PDF]

, 2019
Fien, S ORCiD: 0000-0003-0181-5458BACKGROUND AND PURPOSE: Low and slowing gait speeds among nursing home residents are linked to a higher risk of disability, cognitive impairment, falls, and mortality.
Climstein, Mike, Fien, Samantha, Henwood, Timothy, Keogh, Justin William Leslie, Rathbone, Evelyne   +4 more
core   +2 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Aversive Pavlovian responses affect human instrumental motor performance

Frontiers in Neuroscience, 2012
In neuroscience and psychology, an influential perspective distinguishes between two kinds of behavioural control: instrumental (habitual and goal-directed) and Pavlovian.
Francesco eRigoli, Francesco eRigoli, Enea Francesco Pavone, Giovanni ePezzulo, Giovanni ePezzulo   +4 more
doaj   +1 more source

Why is Voting Habit-Forming: Evidence from Sweden [PDF]

, 2010
For decades, scholars of electoral behavior have noted persistence in individuals' turnout decisions and hypothesized that such persistence is the result of habit.
Melton, James
core  

Planned, motivated and habitual hygiene behaviour: an eleven country review. [PDF]

, 2009
Handwashing with soap (HWWS) may be one of the most cost-effective means of preventing infection in developing countries. However, HWWS is rare in these settings. We reviewed the results of formative research studies from 11 countries so as to understand
Aunger, Robert V, Curtis, Valerie A, Danquah, Lisa O   +2 more
core   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

On the habitual nature of environmentally relevant behavior: Evidence from a consequential dilemma task

Current Research in Ecological and Social Psychology, 2022
Environmentally relevant behaviors are often asserted to be habitual. The present paper challenges this notion by illustrating the difficulty to establish the habitual nature of human behavior.
Florian Lange
doaj   +1 more source

Predictors of Social Media Self-Control Failure: Immediate Gratifications, Habitual Checking, Ubiquity, and Notifications

Cyberpsychology, Behavior, and Social Networking, 2019
Social media users often experience the difficulty of controlling their social media use while having important tasks to do. Recent theorizing on self-control and media use proposes four possible factors (immediate gratifications, habitual checking ...
Jie Du, P. Kerkhof, G. V. Koningsbruggen
semanticscholar   +1 more source