Results 111 to 120 of about 94,938 (303)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
, 2018 Catherine J Vossen,1 Rosan Luijcks,2 Jim van Os,2,3 Elbert A Joosten,1 Richel Lousberg2 1Department of Anaesthesiology and Pain Medicine, 2Department of Psychiatry & Psychology, Maastricht University Medical Centre, Maastricht, The Netherlands; 3King&
Joosten EA +4 more
core
Zoologia (Curitiba), 2010 Adequate habituation of free-ranging subjects is essential for any field study, but is generally unsystematic. Here, attempts to habituate three titi monkey (Callicebus coimbrai Kobayashi & Langguth, 1999) groups are described, and factors determining ...
João Pedro Souza-Alves +1 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Insula-amygdala functional connectivity is correlated with habituation to repeated negative images
, 2014 Behavioral habituation during repeated exposure to aversive stimuli is an adaptive process. However, the way in which changes in self-reported emotional experience are related to the neural mechanisms supporting habituation remains unclear.
Rimsky, Liza +8 more
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Measuring Habituation During Exposure Therapy
This project will estimate the estimated reliability for typically-used calculations of within-subject habituation (WSH) and between-subject habituation (BSH) in studies measuring habituation using subjective units of distress (SUDS) self-report measures.
Emma Dear, Thomas Rodebaugh
core +1 more source
, 2009 The most commonly cited descriptions of the behavioral characteristics of habituation come from two papers published almost 40 years ago [Groves, P. M., & Thompson, R. F. (1970). Habituation: A dual-process theory.
BARRY RJ +13 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source