Results 71 to 80 of about 25,023 (261)

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Haematocrit Distribution in Coronary Arteries: A ROM-PINN and Data-Driven Approach for Predicting Multiphase Flow

Fluids
Blood is a multiphase fluid, constituted of a plasma phase and a red blood cell (RBC) phase. Predicting the distribution of the RBC phase has applications in terms of medical device design, and for the characterisation of the risk of thrombus formation ...
Bharath Sharma, William Fox, Jianhua Chen, Daniel M. Espino, Marco Castellani   +4 more
doaj   +1 more source

The Prevalence of Hipodermosis in Cattle from South-West Side of the Country

Scientific Papers Animal Science and Biotechnologies, 2023
Parasitic disease of domestic and  wild herbivores, hypodermosis is caused by the larval forms of warble fly species. This study aimed the emphasizing of hypodermosis prevalence in cattle from the south-western part of the country, in Mehedinţi district.
Daniela Moţ, Teodor Moţ, Emil Tîrziu, Ileana Nichita   +3 more
doaj  

Electron compensation‐gated nanomotor for immunomodulation and microenvironment remodeling in bacterial pneumonia therapy

BMEMat, EarlyView.
A nanomotor featuring an “electronic lock” via electron compensation in an Au‐Ag alloy ensures therapeutic precision. Near‐infrared light acts as a key, unlocking on‐demand Ag+ release for synergistic bactericidal action and microenvironment remodeling to potently treat bacterial pneumonia. Abstract Bacterial pneumonia treatment is severely hampered by
Chenglong Xue, Xiaoyu Zhao, Yuqian Wang, Lijin Shi, Qi Shuai   +4 more
wiley   +1 more source

Fluid-Structure Interaction in Abdominal Aortic Aneurysms: Effect of Haematocrit

Fluids, 2019
The Abdominal Aortic Aneurysm (AAA) is a local dilation of the abdominal aorta and it is a cause for serious concern because of the high mortality associated with its rupture.
Yorgos G. Stergiou, Athanasios G. Kanaris, Aikaterini A. Mouza, Spiros V. Paras   +3 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

HAEMATOLOGICAL PREDICTORS OF THE ACUTE COURSE OF ANEURYSMAL SUBARACHNOID HAEMORRHAGE

Acta Medica Leopoliensia
Anaemia affects nearly half of patients with aneurysmal subarachnoid haemorrhage (aSAH). Low haemoglobin (Hb) level is associated with more severe clinical conditions and poorer outcomes.
Yuliia Solodovnikova, Anastasiia Revurko, Anatoliy Son   +2 more
doaj   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Effects of Heat Stress on Some Physiological Indicators to the Broilers Cobb

Scientific Papers Animal Science and Biotechnologies, 2023
Four groups of Cobb broilers aged 14 days and average body weight of 480 g, grown in terms of age-appropriate diets were exposed to elevated ambient temperatures 38º-40ºC, varying by experimental scheme for a period of three weeks.
Daniel Cucă, Cristina Dinu
doaj  

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source