Results 191 to 200 of about 86,732 (264)

An open-source, configurable machine learning pipeline for predicting blood culture outcomes from routine haematology parameters. [PDF]

Access Microbiol
McFadden BR, Inglis TJJ, Reynolds M.
europepmc   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

"MyLogbook-I Know My Way Around": A Psychological Therapy Program to Enhance Health Literacy and Positive Emotional Adjustment in Pediatric Oncology. [PDF]

Psychooncology
Weiler-Wichtl LJ, Fohn-Erhold V, Rosenmayr V, Hansl R, Hopfgartner M, Fries J, Schneider C, Herzog K, Neumann K, Schellenberg T, Schönenberger-Loppacher D, Faist-Schweika C, Schönthaler B, Stember N, Wiegele K, Reddig M, Paduch A, Lein-Köhler I, Hoffmann R, Kollmann A, Just U, Salzmann N, Gerhardt M, Essl S, Borbely J, Köpper M, Pal-Handl K, Wasinger-Brandweiner V, Rinner S, Schubert L, Lange S, Leiss U.   +31 more
europepmc   +1 more source

Black Hole Quencher‐Enhanced Plasmonic Photothermal Conversion

Advanced Science, EarlyView.
Researchers have developed a universal method to boost plasmonic photothermal conversion by attaching black hole quencher (BHQ) molecules to matched metal nanostructures. This hybrid approach increases efficiency by roughly threefold, reaching up to 69.1% in the near‐infrared‐II window.
Ruiyuan Zhang, Xinru Chen, Lin Shen, Jin Li   +3 more
wiley   +1 more source

Service delivery interventions for lipid testing and lipid-lowering therapy for primary and secondary prevention of cardiovascular disease in adults. [PDF]

Cochrane Database Syst Rev
Zorger AM, Muth A, Shokraee K, Olfati S, Monsef I, Franco JV, Skoetz N.   +6 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Cow hooves and clover: Unusual morphology of peripheral T-cell lymphoma. [PDF]

Br J Haematol
Lu Y, Preston G, Laing G, Scott P.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The Relationship Between Paediatric Nurses' Perceptions of Family Presence During Resuscitation and Their Self-Confidence Levels. [PDF]

Nurs Crit Care
Kılınç D, Kaygusuz EH.
europepmc   +1 more source