Results 91 to 100 of about 28,636 (337)

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

Decoding the regulatory network of early blood development from single-cell gene expression measurements. [PDF]

, 2015
Reconstruction of the molecular pathways controlling organ development has been hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a strategy to address this problem that combines gene expression profiling of large ...
A Dobin, A Gandillet, A Garg, A Ståhlberg, AC Wilkinson, Adam C Wilkinson, Andrew J Lilly, AS Koksal, Berthold Göttgens, C Pina, C Trapnell, CT Lux, E-AD Amir, Evangelia Diamanti, F Shalaby, F Shalaby, F Tang, Fabian J Theis, Florian Buettner, G Costa, G Ding, G Guo, G Guo, G Swiers, H Kataoka, H Xu, HKA Mikkola, Iain C Macaulay, IM Samokhvalov, J Krumsiek, J Tischler, JA Thoms, Jasmin Fisher, JE Pimanda, JP Thiery, K Sachs, KM Downs, L Robb, L Van der Maaten, L Yan, Laleh Haghverdi, M Kyba, M Sánchez-Castillo, MJ Chen, MT Mitjavila-Garcia, N Bonzanni, N Kabrun, N Sacilotto, Nir Piterman, NK Wilson, NTJ Bailey, R Fan, RA Shivdasani, RB Lorsbach, RR Coifman, S Picelli, S Sumanas, S Taoudi, S Wareing, Shin-Ichi Nishikawa, SJ Loughran, Steven Woodhouse, T North, TM Magin, TM Schlaeger, V Moignard, V Moignard, Valerie Kouskoff, Victoria Moignard, Wajid Jawaid, Y Fujiwara, Y Tanaka, Yosuke Tanaka, Z Xue   +73 more
core   +3 more sources

Role of Gpr56 in mammalian haematopoiesis

, 2021
Haematopoietic stem cells (HSCs) can differentiate into all blood cell types, making HSC transplantation a promising treatment for many blood-related disorders. Allogenic heathy HSCs can be transplanted into patients, although this approach is limited by availability and compatibility of the donor. Moreover, there are no protocols available to generate
openaire   +4 more sources

SensRORing cholesterol to drive protumoral myelopoiesis

Molecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source

HoxA3 is an apical regulator of haemogenic endothelium. [PDF]

, 2011
During development, haemogenesis occurs invariably at sites of vasculogenesis. Between embryonic day (E) 9.5 and E10.5 in mice, endothelial cells in the caudal part of the dorsal aorta generate haematopoietic stem cells and are referred to as haemogenic ...
Caprioli, Arianna, Chong, Diana, Cleaver, Ondine, Hartweck, Lynn, Iacovino, Michelina, Kyba, Michael, Rux, Danielle, Szatmari, Istvan   +7 more
core  

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Haematopoiesis, no hedgehog needed [PDF]

Nature Reports Stem Cells, 2009
A surprising finding has implications for treating blood cancers and for assessing the results of genetic ...
openaire   +2 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Histiocytic sarcoma simulating immune thrombocytopenic purpura [PDF]

, 2012
published_or_final_versio
Hwang, YY, Kwong, YL, Leung, RYY, Sim, PYJ, So, JCC   +4 more
core   +2 more sources