Results 91 to 100 of about 10,512 (289)

A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA

open access: yesAdvanced Functional Materials, EarlyView.
A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi   +5 more
wiley   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

open access: yesAdvanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui   +10 more
wiley   +1 more source

The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner

open access: yesFrontiers in Tropical Diseases
The parasitic worm-derived immunomodulator, ES-62 rescues defective levels of IL-10-producing regulatory B cells (Bregs) and suppresses chronic Th1/Th17-driven inflammation to protect against joint destruction in the mouse collagen-induced arthritis (CIA)
Margaret M. Harnett   +9 more
doaj   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

open access: yesAdvanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain   +2 more
wiley   +1 more source

The role of glucocorticoids in erythropoiesis

open access: yesFrontiers in Hematology
Erythropoiesis is a critical homeostatic process responsible for the production of red blood cells, essential for oxygen delivery to tissues. This review provides a brief overview of erythropoiesis: the maturation of hematopoietic stem cells to ...
Lars L. P. Hanssen   +2 more
doaj   +1 more source

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer   +4 more
wiley   +1 more source

Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting

open access: yesJournal of Extracellular Vesicles
Haematopoiesis dysregulation with the presence of immature myeloid and erythroid immunosuppressive cells are key characteristics of the immune escape phase of tumour development.
Doste R. Mamand   +10 more
doaj   +1 more source

P1340: MONOCYTE-DRIVEN INFLAMMATION IN DNMT3A-MUTANT CLONAL HAEMATOPOIESIS ACUTE ST-ELEVATION MYOCARDIAL INFARCTION.

open access: gold, 2023
Sarah Mackie   +8 more
openalex   +1 more source

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