Results 151 to 160 of about 13,881 (340)

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao, Yikun Yao, Weilong Li, Zigan Xu, Wenjun Hu, Kewang Luo, Peishan Chen, Wanjing Shang, Shaodong Luan, Guojun Shi, Mengtao Cao, Pengfei Chen   +11 more
wiley   +1 more source

Loss of Golga7 Suppresses Oncogenic Nras‐Driven Leukemogenesis without Detectable Toxicity in Adult Mice

Advanced Science, EarlyView.
NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Chenxuan Liu, Peihong Wang, Pengfei Xu, Jinzeng Wang, Zhou Fang, Donghe Li, Zhizhou Xia, Jiaoyang Li, Shiyu Ji, Qianqian Zhang, Min Wu, Shengyue Wang, Ping Liu, Ruibao Ren   +18 more
wiley   +1 more source

Mini review of metabolism in leukaemia: from complexity to the clinic

Frontiers in Hematology
The importance of metabolism to cancer has increasingly been recognised and this is particularly the case for leukaemia. This has opened the possibility of targeting dysregulated metabolism with the aim of increasing the effectiveness of current ...
Kevin M. Rattigan
doaj   +1 more source

Bone morphogenetic protein 4 modulates c‐Kit expression and differentiation potential in murine embryonic aorta‐gonad‐mesonephros haematopoiesis in vitro [PDF]

, 2007
Caroline Marshall, Joanna Sinclair, Adrian J. Thrasher, Christine Kinnon   +3 more
openalex   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

The immunolocalization of HIF‐2α, GLUT1 and CAIX in porcine oviduct during the estrous cycle

The Anatomical Record, Volume 306, Issue 1, Page 176-186, January 2023., 2023
Abstract Oxygen (O2) rates in the oviduct are essential to human and animal reproduction. These rates are regulated by the activity of hypoxia markers such as the hypoxia‐inducible factors (HIFs), the glucose transporters (GLUT), and the carbonic anhydrase (CA).
Ester Párraga‐Ros, Rafael Latorre‐Reviriego, Mónica Aparicio‐González, Talía Boronat‐Belda, Octavio López‐Albors   +4 more
wiley   +1 more source

Exploring the regenerative capacity of the spleen following irradiation

Frontiers in Hematology
IntroductionHaematopoietic stem cell transplantation (HSCT) is commonly used to treat patients with haematological disorders. Myeloablative conditioning is an important preparation for patients receiving haematopoietic stem cells (HSC) or haematopoietic ...
Christie T. M. Short, Helen C. O’Neill, Jonathan K. H. Tan   +2 more
doaj   +1 more source

Selective role of calcineurin in haematopoiesis and lymphopoiesis [PDF]

, 2008
Elena Gallo, Lena Ho, Monte M. Winslow, Tracy Staton, Robert H. Crabtree   +4 more
openalex   +1 more source

Advancing Allogeneic NK Cell Immunotherapy through Microfluidic Gene Delivery

Advanced Science, EarlyView.
The Y‐Hydroporator is a microfluidic gene delivery platform designed for allogeneic NK cell‐based immunotherapies. It achieves highly efficient gene delivery while preserving high cell viability and functionality. By producing engineered NK cells with enhanced cytotoxicity, the platform addresses critical limitations of autologous cell therapy ...
Hyelee Kim, Mujin Lee, Bohwa Han, Jinho Kim, Duck Cho, Junsang Doh, Aram J. Chung   +6 more
wiley   +1 more source

The role of glucocorticoids in erythropoiesis

Frontiers in Hematology
Erythropoiesis is a critical homeostatic process responsible for the production of red blood cells, essential for oxygen delivery to tissues. This review provides a brief overview of erythropoiesis: the maturation of hematopoietic stem cells to ...
Lars L. P. Hanssen, Deena Iskander, Deena Iskander   +2 more
doaj   +1 more source