Results 191 to 200 of about 10,512 (289)

The role of Notch and GATA3 in postnatal and adult haematopoiesis

, 2011
Sara Duarte
openalex   +2 more sources

How haematopoiesis research became a fertile ground for regulatory network biology as pioneered by Eric Davidson

, 2020
Ellen V. Rothenberg, Berthold Göttgens
openalex   +2 more sources

Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies [PDF]

, 2009
Miłosz Kawa, Katarzyna Grymuła, Edyta Paczkowska, Magdalena Baśkiewicz‐Masiuk, E Dabkowska, Monika Koziołek, Maciej Tarnowski, Patrycja Kłos, Violetta Dziedziejko, Magda Kucia, Anhelli Syrenicz, Bogusław Machaliński   +11 more
openalex   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

What's new in heart failure? September 2025. [PDF]

Eur J Heart Fail
Hoevelmann J, Markwirth P, Tokcan M, Haring B.   +3 more
europepmc   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Primary CD34⁺ cells of patients with vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome are highly sensitive to targeted treatment with TAK-243. [PDF]

Br J Haematol
Nowak D, Demmerle M, Klär A, Streuer A, Riabov V, Altrock E, Rapp F, Belzer AC, Klink T, Hahn M, Hofmann F, Nowak V, Weimer N, Obländer J, Palme I, Göl M, Darwich A, Steiner L, Abba M, Metzgeroth G, Hofmann WK, Schmitt N.   +21 more
europepmc   +1 more source

A novel ultrasound-based approach to investigate extramedullary haematopoiesis in foetal spleen.

, 2021
Marcello Roberto, Gianmario Pasqualone, Nicola G Di Donato, Zaheer Malik, Sheereen Bhaiyat, Vito Ca Caponio, Giuseppe Lillo, Gianfranco Vallone, Ciro R. Rinaldi, Vincenzo Martinelli   +9 more
openalex   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis. [PDF]

Cardiovasc Res
Gerhardt T, Huynh P, McAlpine CS.
europepmc   +1 more source