Results 301 to 310 of about 13,881 (340)
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Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock
European Journal of Heart Failure, 2022Cardiogenic shock (CS) with variable systemic inflammation may be responsible for patient heterogeneity and the exceedingly high mortality rate. Cardiovascular events have been associated with clonal haematopoiesis (CH) where specific gene mutations in ...
F. Scolari +14 more
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Intrathoracic extramedullary haematopoiesis
Postgraduate Medical Journal, 2019A woman from the Middle East, in her fifth decade, known to have beta thalassemia while undergoing routine medical assessment was incidentally detected to have a mass lesion in the right lower zone on chest radiograph (figure 1). On clinical assessment she was found to have hepatosplenomegaly. Respiratory system examination was unremarkable.
Padmanabhan Arjun, Mathew Thomas
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Haematopoiesis, or Blood Poetry
Perspectives in Biology and Medicine, 2020"It was just a few small red dots," I would recount to innumerable sympathetic nurses. They-the dots, not nurses-clustered together on my son's smooth slim neck. I stroked them as I dressed him after the bath. My inner hypochondriac was oddly quiet. Larry, my son, was well, throwing himself through the world with speed, joy, and curiosity. The next day
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Cellular interactions in haematopoiesis
Nature, 1979In vitro culture of haematopoietic cells has provided some surprising insights into critical interactions of blood-forming cells. Subpopulations of lymphoid cells have been shown to produce colony-stimulating activity, to interact with macrophages, and to have important effects on the very early stages of erythropoiesis.
Martin J. Cline, David W. Golde
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Cohesin in haematopoiesis and leukaemia
Current Opinion in Hematology, 2018Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic ...
Jonas Larsson, Roman Galeev
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Developmental & Comparative Immunology, 2016
Marsupials are a group of mammals that give birth to immature young lacking mature immune tissues at birth, and are unable to mount their own specific immune defence. Their immune tissues develop in a non-sterile ex-utero environment unlike that of eutherian mammals such as ourselves.
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Marsupials are a group of mammals that give birth to immature young lacking mature immune tissues at birth, and are unable to mount their own specific immune defence. Their immune tissues develop in a non-sterile ex-utero environment unlike that of eutherian mammals such as ourselves.
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European Heart Journal
BACKGROUND AND AIMS Both clonal haematopoiesis of indeterminate potential (CHIP) and atrial fibrillation (AF) are age-related conditions. This study investigated the potential role of CHIP in the development and progression of AF. METHODS Deep-targeted
H. Ahn +16 more
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BACKGROUND AND AIMS Both clonal haematopoiesis of indeterminate potential (CHIP) and atrial fibrillation (AF) are age-related conditions. This study investigated the potential role of CHIP in the development and progression of AF. METHODS Deep-targeted
H. Ahn +16 more
semanticscholar +1 more source
European Heart Journal, 2020
AIMS Somatic mutations of the epigenetic regulators DNMT3A and TET2 causing clonal expansion of haematopoietic cells (clonal haematopoiesis; CH) were shown to be associated with poor prognosis in chronic ischaemic heart failure (CHF).
B. Assmus +15 more
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AIMS Somatic mutations of the epigenetic regulators DNMT3A and TET2 causing clonal expansion of haematopoietic cells (clonal haematopoiesis; CH) were shown to be associated with poor prognosis in chronic ischaemic heart failure (CHF).
B. Assmus +15 more
semanticscholar +1 more source
Clonal haematopoiesis of emerging significance
Pathology, 2021Clonal haematopoiesis (CH) is a ubiquitous feature of aging and provides mechanistic insight into the inextricable relationship between chronic inflammation and age-related diseases. Although CH confers a cumulative risk of subsequent haematological malignancy, particularly myeloid neoplasms, that risk is heavily mutation- and context-specific ...
Danielle Hammond, Sanam Loghavi
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The role of cytokines in haematopoiesis
European Journal of Haematology, 1996Abstract: Cytokines, by definition, exert an effect on haematopoiesis. Diseases characterized by haematopoietic insufficiency, such as aplastic anaemia, should therefore be investigated for abnormal expression of these regulatory proteins. In studies on hairy cell leukaemia, a severe deficiency was found in the production of interleukin‐3 (IL‐3 ...
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