A newly identified gene Ahed plays essential roles in murine haematopoiesis
Nature CommunicationsThe development of haematopoiesis involves the coordinated action of numerous genes, some of which are implicated in haematological malignancies. However, the biological function of many genes remains elusive and unknown functional genes are likely to ...
Ritsuko Nakai +19 more
doaj +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Decoding the regulatory network of early blood development from single-cell gene expression measurements. [PDF]
, 2015 Reconstruction of the molecular pathways controlling organ development has been hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a strategy to address this problem that combines gene expression profiling of large ...
A Dobin +73 more
core +3 more sources
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
MAPK p38alpha Kinase Influences Haematopoiesis in Embryonic Stem Cells
Stem Cells International, 2019 The activation of p38alpha kinase mediates cell response to various extracellular factors including many interleukins and growth factors important for haematopoiesis. The role of p38alpha kinase was previously analysed in particular haematopoietic cells.
Kateřina Štefková +6 more
doaj +1 more source
Autophagy in endothelial cells regulates their haematopoiesis-supporting ability
EBioMedicine, 2020 Background: Endothelial cells (ECs) function as an instructive platform to support haematopoietic stem cell (HSC) homeostasis. Our recent studies found that impaired bone marrow (BM) ECs are responsible for the defective haematopoiesis in patients with ...
Zhong-Shi Lyu +11 more
doaj +1 more source
The ontogeny of haematopoiesis in the marine teleost Leiostomus xanthurus and a comparison of the site of initial haematopoiesis with Opsanus tau [PDF]
, 2005 The ontogeny of haematopoiesis in the perciform fish, spot Leiostomus xanthurus, differed from that reported as the norm for fishes, as exemplified by the cypriniform zebrafish Danio rerio, and observed in the batrachoidiform oyster toadfish Opsanus tau.
Bonaventura, J. +4 more
core +1 more source
Therapy-related leukaemias with balanced translocations can arise from pre-existing clonal haematopoiesis [PDF]
, 2021 Richard Dillon +14 more
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic +6 more
wiley +1 more source
Distinctive functions of methionine aminopeptidase II in embryonic haematopoiesis in zebrafish embryos [PDF]
, 2010 Oral presentationINTRODUCTION: Methionine aminopeptidase 2 (MetAP-2) is known to be the target of an anti-angiogenesis compound fumagillin and has been investigated for its robust expression in human cancers and its antiproliferative effects on ...
Chung, MIS +5 more
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