Results 81 to 90 of about 22,415 (245)
Thalasaaemia and extramedullary haematopoiesis [PDF]
QJM: An International Journal of Medicine, 2019 C R Kopp +4 more
openaire +3 more sources
Advanced Science, EarlyView.Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen +12 more
wiley +1 more source
Two Chinese patients with Loeys-Dietz Syndrome due to TGFBR2 mutations [PDF]
, 2011 Poster Presentation (Doctor’s Session)This journal issue contain Proceedings of the CongressBACKGROUND: We previously reported 6 patients with Marfan-like phenotype due to transforming growth factor b-receptor 2 (TGFBR2) mutations (Am J Med Genet Part A ...
Chan, SY +6 more
core
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
Advanced Science, EarlyView.MetaTF is a new computational framework that uses single‐cell RNA sequencing (scRNA‐seq) data to infer transcription factor activity with the aim to help in deciphering cells identity starting from a heterogeneous population, and apply it to characterize mouse hematopoietic stem cells and breast cancer epithelial cells, thus identifying a novel subset ...
Yongfei Hu +15 more
wiley +1 more source
Advanced Science, EarlyView.Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang +4 more
wiley +1 more source
Intracerebral haemorrhage complicating anticoagulant therapy among Hong Kong Chinese [PDF]
, 2010 PosterBACKGROUND: Anticoagulation is effective to prevent cardioembolism in patients with atrial fibrillation (AF) and prosthetic heart valves, but carries risk of potentially life-threatening intracerebral haemorrhage (ICH).
Chan, KH +6 more
core
Advanced Science, EarlyView.This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao +7 more
wiley +1 more source
Advanced Science, EarlyView.DeepCCDS leverages prior knowledge and self‐supervised learning to model cancer driver signals for drug sensitivity prediction. It captures complex regulatory patterns enabling more biologically informed representations. The framework outperforms existing methods across datasets, offering improved accuracy and interpretability.
Jiashuo Wu +10 more
wiley +1 more source
Recent Advances in mRNA Delivery Systems for Cancer Therapy
Advanced Science, EarlyView.This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang +9 more
wiley +1 more source