Results 61 to 70 of about 429,520 (307)

Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies [PDF]

, 2014
This study sought to correlate faecal and urinary N-methylhistamine (NMH) concentrations with resting versus degranulated duodenal mast cell numbers in dogs with chronic enteropathies (CE), and investigate correlations between intestinal mast cell ...
Allenspach, K, Anfinsen, K P, Berghoff, N, Priestnall, S L, Steiner, J M, Suchodolski, J S   +5 more
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The effects of irisin on the rat thoracic aorta: a histological study

Folia Morphologica, 2022
BACKGROUND: Irisin, a polypeptide hormone that is released from skeletal muscle in response to exercise, has been found to improve endothelial functions, protect against endothelial injuries and change blood pressure, which also affected blood vessels ...
R. Altaweel, A. Shatarat, D. Badran, N. M. Abu Tarboush   +3 more
doaj   +1 more source

Causes of mortality and characterisation of Mycobacteriosis in adult New Zealand sea lions (Phocarctos Hookeri) at Enderby Island : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Science in Wildlife Health at Massey University, Manawatū, Palmerston North, New Zealand [PDF]

, 2017
The New Zealand sea lion (Phocarctos hookeri) is classified as endangered and “Nationally Critical” due to a declining population and restricted population range. There have been recent bacterial epizootic events at the breeding colonies of this species,
Lenting, Baukje Mirjam
core  

Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]

, 2011
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne, Rutsch, Frank, Terkeltaub, Robert, Weissen-Plenz, Gabriele   +3 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Modelling aspects of oviduct fluid formation in vitro [PDF]

, 2016
© 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation.
Arnold, Georg, Arnold, Georg J., Froehlich, Thomas, Fröhlich, Thomas, Leese, Henry, Leese, Henry J., Sathyapalan, Thozhukat, Simintiras, Constantine A., Sturmey, Roger, Sturmey, Roger G., Ulbrich, Susanne, Ulbrich, Susanne E.   +11 more
core   +2 more sources

Segmentation of epidermal tissue with histopathological damage in images of haematoxylin and eosin stained human skin [PDF]

BMC Medical Imaging, 2014
Digital image analysis has the potential to address issues surrounding traditional histological techniques including a lack of objectivity and high variability, through the application of quantitative analysis. A key initial step in image analysis is the identification of regions of interest. A widely applied methodology is that of segmentation.
Haggerty JM, Wang XN, Dickinson A, O'Malley CJ, Martin EB   +4 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Evaluation of diagnostic reliability of micronuclei in potentially malignant disorders of oral cavity

CHRISMED Journal of Health and Research, 2014
Context: Micronucleus (MN) has been proved to be an important biomarker of genomic damage. MN scoring in oral exfoliated epithelial cells has been used in the past as a biomarker to identify different preneoplastic conditions much earlier than the ...
Sonal Grover, Mujib BR Ahmed, Neethu Telagi, Anil B Shivappa, K P Nithin   +4 more
doaj   +1 more source