Results 181 to 190 of about 159,392 (269)

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Upper gastrointestinal bleeding in a term neonate requiring haemostasis by laparotomy. [PDF]

BMJ Case Rep
Yamamoto Y, Mizumoto H, Fukuzawa H.
europepmc   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

High-dose, short-course primaquine after point-of-care G6PD testing for the radical cure of <i>Plasmodium vivax</i> malaria: a safety study in Papua New Guinea and Indonesia. [PDF]

Lancet Reg Health West Pac
Fransisca L, Ome-Kaius M, Laman M, Poespoprodjo JR, Pasaribu AP, Sutanto I, Malai M, Nelwan E, Adella J, Abegini C, Ainur F, Amdara Y, Angeline S, Brown K, Burdam FH, Curry E, Daimen M, Daly P, Do T, Dori A, Douglas NM, Huegel H, Hutagalung AP, Jambert E, Jimanto V, Karo V, Kenangalem E, Kelebi T, Kisomb J, Laksono I, Lee G, Ley B, Mannion K, Plinduo J, Pukai I, Putri A, Rajasekhar M, Ronkentou S, Rosens E, Sakalidis VS, Satyagraha A, Simpson JA, Theodora M, Ubra R, Vakore N, Wansom T, Duparc S, Robinson LJ, Price RN.   +48 more
europepmc   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Anaemia and Maternal Iron Intakes in Pregnancy and Child Asthma: An Observational Analysis From a Longitudinal Cohort. [PDF]

Health Sci Rep
Hokey E, Callanan S, Delahunt A, Douglass A, Talaei M, Shaheen SO, McAuliffe FM.   +6 more
europepmc   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

Cemented versus uncemented stems in total hip arthroplasty: No independent effect on transfusion or complications despite reduced total blood loss. [PDF]

J Exp Orthop
Ramadanov N, Fuchs D, Heinz M, Prill R, Becker R.   +4 more
europepmc   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source